In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

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dc.contributorRenata B. S. Lima; Luiz F. Rocha e Silva; Marcia R. S. Melo; Jaqueline S. Costa; Neila S. Picanço; Emerson S. Lima; Marne C. Vasconcellos; Ana Paula A. Boleti; Jakeline M. P. Santos; Rodrigo C. N. Amorim; FRANCISCO CELIO MAIA CHAVES, CPAA; Julia P. Coutinho; Wanderli P. Tadei, INPA; Antoniana U. Krettli; Adrian M. Pohlit.
dc.creatorLIMA, R. B. S.
dc.creatorSILVA, L. F. R. e
dc.creatorMELO, M. R. S.
dc.creatorCOSTA, J. S.
dc.creatorPICANÇO, N. S.
dc.creatorLIMA, E. S.
dc.creatorVASCONCELLOS, M. C.
dc.creatorBOLETI, A. P. A.
dc.creatorSANTOS, J. M. P.
dc.creatorAMORIM, R. C. N.
dc.creatorCHAVES, F. C. M.
dc.creatorCOUTINHO, J. P.
dc.creatorTADEI, W. P.
dc.creatorKRETTLI, A. U.
dc.creatorPOHLIT, A. M.
dc.date2015-12-21T11:11:11Z
dc.date2015-12-21T11:11:11Z
dc.date2015-12-21
dc.date2015
dc.date2016-03-01T11:11:11Z
dc.date.accessioned2026-06-30T23:21:49Z
dc.descriptionThe anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.
dc.identifierMalaria Journal, v. 14, p. 1-14, Dec. 2015.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1032178
dc.identifierdoi:10.1186/s12936-015-0999-2
dc.identifier.urihttp://hdl.handle.net/123456789/380044
dc.languageeng
dc.rightsopenAccess
dc.subjectAntiplasmodial
dc.subjectCytotoxic
dc.subjectAndropogon leucostachyus
dc.subjectXylopia amazonica
dc.subjectZanthoxylum djalma-batistae
dc.subjectAnacardium Occidentale
dc.subjectPaullinia Cupana
dc.subjectCroton cajucara
dc.subjectPlasmodium berghei
dc.subjectPlasmodium falciparum
dc.subjectmalaria
dc.titleIn vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.
dc.typeArtigo de periódico

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Embrapa Amazonía Occidental (CPAA)