In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

LIMA, R. B. S.; SILVA, L. F. R. e; MELO, M. R. S.; COSTA, J. S.; PICANÇO, N. S.; LIMA, E. S.; VASCONCELLOS, M. C.; BOLETI, A. P. A.; SANTOS, J. M. P.; AMORIM, R. C. N.; CHAVES, F. C. M.; COUTINHO, J. P.; TADEI, W. P.; KRETTLI, A. U.; POHLIT, A. M.

In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

Autores

Descripción

The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.

Palabras clave

Antiplasmodial, Cytotoxic, Andropogon leucostachyus, Xylopia amazonica, Zanthoxylum djalma-batistae, Anacardium Occidentale, Paullinia Cupana, Croton cajucara, Plasmodium berghei, Plasmodium falciparum, malaria