Sisapronil. Residue Monograph of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 81st meeting 2015
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FAO/WHO ;
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Sisapronil is a member of the phenylpyrazole class of antiparasitics. It is a long-acting subcutaneous injectable ectoparasiticide for control of cattle ticks. It also aids in the control of bot fly larvae, hornfly and screwworm. Sisapronil binds tightly to ligand-gated chloride channels, in particular those gated by the neurotransmitter gamma-aminobutyric acid (GABA), blocking the pre- and post-synaptic transference of chloride ions through cell membranes in insects or mites, exposed through in gestion or contact. This mechanism of action results in hyperexcitability of the central nervous system and death of the parasites. Sisapronil has been registered for use in Brazil with a withdrawal period of 120 days.