A compact miniaturized flow system based on low-temperature co-fired ceramic technology coupled to led mini-photometer for determination of dipyrone in pharmaceutical formulations.

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dc.contributorWILLIAN T. SUAREZ, Universidade Federal de Viçosa; OSMUNDO D. PESSOA-NETO, Universidade Federal de São Carlos; VAGNER B. DOS SANTOS, Universidade Federal de São Carlos; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; RONALDO C. FARIA, Universidade Federal de São Carlos; ORLANDO FATIBELLO-FILHO, Universidade Federal de São Carlos; JULIÁN A. CHAMARRO, Universitat Autònoma de Barcelona.
dc.creatorSUAREZ, W. T.
dc.creatorPESSOA NETO, O. D.
dc.creatorSANTOS, V. B. dos
dc.creatorNOGUEIRA, A. R. de A.
dc.creatorFARIA, R. C.
dc.creatorFATIBELLO-FILHO, O.
dc.creatorCHAMARRO, J. A.
dc.date2023-05-15T12:47:12Z
dc.date2023-05-15T12:47:12Z
dc.date2013-06-04
dc.date2013
dc.date.accessioned2026-07-07T05:31:49Z
dc.descriptionIn this work, an analytical microsystem based on LTCC (low-temperature co-fired ceramic) technology with monolithic incorporation of an optical flow cell for determination of dipyrone in pharmaceuticals is described. The detection system is based on the formation of a blue chromophore between dipyrone and Fe(III) photometrically monitored at 630 nm using a lab-made LED mini-photometer constructed with a light emitting diode as a radiation source and a Si photodiode as a detector. The lab-made mini-photometer elaborated presented a good performance in regard to high signal/noise ratio, low drift and good sensitivity. The analytical curve was linear in the dipyrone concentration range from 1.0 × 10-4 to 3.5 × 10-3 mol L-1, limit of detection of 4.5 × 10-5 mol L-1 and total time of analyses of 20 s yielding an analytical frequency of 195 h-1 with a low waste generation per analysis (480 µL).
dc.identifierJournal Brazilian Chemical Society, v. 24, n. 5, p. 847-855, may 2013.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/959237
dc.identifierhttps://doi.org/10.5935/0103-5053.20130112
dc.identifier.urihttp://hdl.handle.net/123456789/493960
dc.languageeng
dc.rightsopenAccess
dc.subjectLow temperature
dc.subjectCo-fired ceramic
dc.subjectAnalytical microsystems
dc.subjectDipyrone
dc.subjectFlow injection
dc.subjectLED photometer
dc.titleA compact miniaturized flow system based on low-temperature co-fired ceramic technology coupled to led mini-photometer for determination of dipyrone in pharmaceutical formulations.
dc.typeArtigo de periódico

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