Bioinspired Engineering ofBombyx mori Silk Fibroin:Solution Blow-Spun Nanofibers Hybridized with (3-Aminopropyl) triethoxysilane.

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dc.contributorUNIVERSITY OF SÃO PAULO (USP); NANOSCIENTIFCA SCANDINAVIAN AB, GOTHENBURG 41 390, SWEDEN; CENTRO UNIVERSITÁRIO DE ARARAQUARA; INSTITUTE OF CHEMISTRY, SÃO PAULO STATE UNIVERSITY (UNESP); SÃO CARLOS INSTITUTE OF PHYSICS (IFSC), UNIVERSITY OF SÃO PAULO (USP); FEDERAL UNIVERSITY OF SÃO CARLOS (UFSCAR); LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA.
dc.creatorSORIGOTTI, A. R.
dc.creatorPASCHOALIN, R. T.
dc.creatorSILVA, R. R. da
dc.creatorFERNANDES, R. F.
dc.creatorBARUD, H. da S.
dc.creatorRIBEIRO, S. J. L.
dc.creatorOLIVEIRA JR, O. N.
dc.creatorOTONI, C. G.
dc.creatorMATTOSO, L. H. C.
dc.date2026-05-22T13:54:45Z
dc.date2026-05-22T13:54:45Z
dc.date2026-05-22
dc.date2026
dc.date.accessioned2026-07-07T04:29:57Z
dc.descriptionThedevelopmentofbioinspirednanofibrousscaffoldswithadjustablefunctionsisessential forarangeofapplications, fromtissueengineeringtosustainablematerialsthatexploitthehierarchicalarchitecturesofBombyxmorisilks.Inthiswork,wereport theproductionoforganic−inorganicnanofibersbyincorporatingtheorganosilane(3-aminopropyl)triethoxysilane(APTES)intosilk fibroinusingthesolutionblowspinning(SB-spinning)technique.TheincorporationofAPTESaimstomodulatesolutionrheological properties,promoteconformational transitiontoβ-sheet-richstructures,andincreasethethermal stabilityof theresultingnanofiber, makingthemmoresuitableforbiomedicalapplications.SilkfibroinwasisolatedfromB.moricocoons,dissolvedinaternaryCaCl2/ EtOH/H2Osolution,andhybridizedwithAPTESbeforefiberproduction.Theresultingnanofibersdisplayedsmooth,uniformmor phologies andnanoscalediameters, confirming theeffectivenessof SB-spinning for creatinghybridsystems.Rheological analyses showedthataddingAPTESreducedviscosityandenhancedtheprocessabilityoffibroinsolutions.SpectroscopicandX-raydiffraction datarevealedanincreasedβ-sheetcontentandcrystallinityinthehybridfibers,whilethermogravimetricanalysisindicatedimproved thermal stability.Overall, theseresultsdemonstrate that incorporatingAPTESeffectivelyalters thephysicochemical andstructural propertiesofsilkfibroin,enablingtheproductionofpromisingnanofibrousscaffoldsforbiomedicalapplications.Thisstudythusintro ducesanapproachtoengineeringorganic−inorganichybridbiomaterialsviaascalable, low-costspinningprocess. KEYWORDS: biopolymers, solutionblowspinning,APTES,hybridnanofibers, tissueengineering
dc.format4170−4181
dc.identifierACS Applied Bio Materials, v. 9, 2026.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1187033
dc.identifierhttps://doi.org/10.1021/acsabm.6c00155
dc.identifier.urihttp://hdl.handle.net/123456789/463227
dc.languageeng
dc.rightsopenAccess
dc.subjectFIbroin nanofibers
dc.subjectAPTES
dc.titleBioinspired Engineering ofBombyx mori Silk Fibroin:Solution Blow-Spun Nanofibers Hybridized with (3-Aminopropyl) triethoxysilane.
dc.typeArtigo de periódico

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