Co-culture of Penicillium setosum and Cryptococcus neoformans reveals the production of antifungal diketopiperazine.
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Co-cultures, also known as mixed fermentations, involves the growth of two or more microorganisms. This approach has emerged as an effective strategy to increase the production of natural products and to boost the activation of cryptic or silent gene clusters responsible for synthesizing new secondary metabolites. Many of these clusters are susceptible to biotic and/or abiotic environmental modifications what may further the production of bioactive compounds as a result of chemical and biological responses.
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Penicillium setosum, Dereplication, Antimicrobials, Diketopiperazines