Molecular evolution of the ? -casp family suggests functional homology with rag1/rag2 proteins: a new model for dna interstrand crosslink repair, nonhomologous end-joining and v(d)j recombination in yeast and vertebrates.

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dc.contributorDIEGO BONATTO, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; LUIS FERNANDO REVERS, CNPUV; MARTIN BRENDEL, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL; JOÃO ANTONIO PÊGAS, UNIVERSIDADE FEDERAL DORIO GRANDE DO SUL.
dc.creatorBONATTO, D.
dc.creatorREVERS, L. F.
dc.creatorBRENDEL, MARTIN
dc.creatorPÊGAS, J. A.
dc.date2025-04-04T18:07:28Z
dc.date2025-04-04T18:07:28Z
dc.date2025-04-04
dc.date2003
dc.date.accessioned2026-07-07T11:31:55Z
dc.descriptionNon-homologous end-joining (NHEJ) and V(D)J recombination are importan t pathways for DNA double strand break repair (DSBR) and for generation of immunological diversity in lymphocytes, respectively. The main feature of both pathways is that they share common protein complexes that recruit NHEJ- or V(D)J-specific proteins. Proteins of the ?-CASP family, functionally related to DNA or RNA metabolism, are necessary for NHEJ and DNA interstrand cross-link repair.
dc.format1 CD-ROM.
dc.format1 P.
dc.identifierCONGRESSO NACIONAL DE GENÉTICA, 49., 2003, Águas de Lindóia. A dupla hélice do DNA: anais. Águas de Lindóia: Sociedade Brasileira de Genética, 2003. gm011.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1174538
dc.identifier.urihttp://hdl.handle.net/123456789/511223
dc.languageeng
dc.rightsopenAccess
dc.subjectNHEJ
dc.subjectNon-homologous end-joining (NHEJ)
dc.subjectDouble strand break repair (DSBR)
dc.subjectRepair
dc.subjectDNA
dc.subjectPhylogeny
dc.titleMolecular evolution of the ? -casp family suggests functional homology with rag1/rag2 proteins: a new model for dna interstrand crosslink repair, nonhomologous end-joining and v(d)j recombination in yeast and vertebrates.
dc.typeResumo em anais e proceedings

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