Molecular evolution of the ? -casp family suggests functional homology with rag1/rag2 proteins: a new model for dna interstrand crosslink repair, nonhomologous end-joining and v(d)j recombination in yeast and vertebrates.
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Non-homologous end-joining (NHEJ) and V(D)J recombination are importan t pathways for DNA double strand break repair (DSBR) and for generation of immunological diversity in lymphocytes, respectively. The main feature of both pathways is that they share common protein complexes that recruit NHEJ- or V(D)J-specific proteins. Proteins of the ?-CASP family, functionally related to DNA or RNA metabolism, are necessary for NHEJ and DNA interstrand cross-link repair.
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NHEJ, Non-homologous end-joining (NHEJ), Double strand break repair (DSBR), Repair, DNA, Phylogeny