Koninginins and related octaketides from Trichoderma and other fungi: chemical diversity and biological activities.

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dc.contributorJOSÉ C. I. SILVA, UNIVERSIDADE DO ESTADO DO AMAZONAS; FELIPE M. A. SILVA, UNIVERSIDADE FEDERAL DO AMAZONAS; GILVAN FERREIRA DA SILVA, CPAA; HECTOR H. F. KOOLEN, UNIVERSIDADE DO ESTADO DO AMAZONAS.
dc.creatorSILVA, J. C. I.
dc.creatorSILVA, F. M. A.
dc.creatorSILVA, G. F. da
dc.creatorKOOLEN, H. H. F.
dc.date2025-12-19T12:48:32Z
dc.date2025-12-19T12:48:32Z
dc.date2025-12-18
dc.date2025
dc.date.accessioned2026-06-30T23:29:01Z
dc.descriptionKoninginins and their derivatives represent a structurally diverse class of octaketides with notable biological activities, including antimicrobial, antiophidic, anti-inflammatory, cytotoxic properties, and potential for regulating plant growth. Originally discovered in 1989 with the isolation of koninginin A by Cutler and colleagues, numerous structural variants, such as koningiopisins, trichoketides, trichodermatides, and trichodermaketones have since been identified. While predominantly produced by Trichoderma species, koninginins have also been reported in other fungi, including basidiomycetes (Pholiota) and ascomycetes (Aspergillus, Penicillium, and Diaporthe). This review systematically compiles and analyzes over 80 compounds described between 1989 and 2024, focusing on their structural skeletons, cyclization patterns, functionalization, stereochemistry, nomenclature, biosynthesis, and biological activities. The findings provide perspectives for future research on this promising class of fungal polyketides.
dc.identifierJournal of the Brazilian Chemical Society, v. 36, n. 11, e-20250110, 2025.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1183069
dc.identifierhttps://doi.org/10.21577/0103-5053.20250110
dc.identifier.urihttp://hdl.handle.net/123456789/383022
dc.languageeng
dc.rightsopenAccess
dc.subjectKoninginin
dc.subjectChemodiversity
dc.subjectBiological activities
dc.subjectTrichoderma
dc.subjectFungo
dc.subjectPolyketides
dc.subjectBiosynthesis
dc.subjectTrichoderma koningii
dc.titleKoninginins and related octaketides from Trichoderma and other fungi: chemical diversity and biological activities.
dc.typeArtigo de periódico

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