Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.

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dc.contributorNayara Simas Frauches, UNIRIO
dc.contributorJúlia Montenegro, UNIRIO
dc.contributorThuane Amaral, UNIRIO
dc.contributorJoel Pimentel Abreu, UNIRIO
dc.contributorGabriela Laiber, UNIRIO
dc.contributorJorge Junior, UFRJ
dc.contributorRENATA GALHARDO BORGUINI, CTAA
dc.contributorMANUELA CRISTINA P DE A SANTIAGO, CTAA
dc.contributorSIDNEY PACHECO, CTAA
dc.contributorVania Mayumi Nakajima, UFF
dc.contributorRONOEL LUIZ DE OLIVEIRA GODOY, CTAA
dc.contributorAnderson Junger Teodoro, UNIRIO.
dc.creatorFRAUCHES, N. S.
dc.creatorMONTENEGRO, J.
dc.creatorAMARAL, T.
dc.creatorABREU, J. P.
dc.creatorLAIBER, G.
dc.creatorJORGE JUNIOR
dc.creatorBORGUINI, R. G.
dc.creatorSANTIAGO, M. C. P. de A.
dc.creatorPACHECO, S.
dc.creatorNAKAJIMA, V. M.
dc.creatorGODOY, R. L. de O.
dc.creatorTEODORO, A. J.
dc.date2021-01-30T00:53:44Z
dc.date2021-01-30T00:53:44Z
dc.date2021-01-27
dc.date2021
dc.date.accessioned2026-06-30T23:10:21Z
dc.descriptionThere is a significant indication of the beneficial health effects of fruit rich diets. Fruitsof native plant species have noticeably different phytochemicals and bioactive effects. The aim ofthis work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ),jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and theirinfluence on antioxidant activityin vitroand antiproliferative effects on human colon adenocarci-noma cells. According to the results, dried peel powders (DP) have a high anthocyanin content,phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD).M.jaboticabadried peel powder extract had a higher total anthocyanin and phenolic compounds content(802.90±1.93 and 2152.92±43.95 mg/100 g, respectively). A reduction in cell viability of HT-29cells after treatment withM. jaboticabaextracts (DP-MJ and FD-MJ) was observed via MTT assay.Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SMhad an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cellsin relation to the control group. The findings of this study highlight the potential of peel powdersfromMyrtaceaefruits as an important source of natural antioxidants and a protective effect againstcolon adenocarcinoma
dc.identifierMolecules, v. 26, n. 564 , 2021. p. 1-16.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1129588
dc.identifierhttps://doi.org/10.3390/molecules26030564
dc.identifier.urihttp://hdl.handle.net/123456789/375741
dc.languageeng
dc.rightsopenAccess
dc.subjectMalay-apple
dc.subjectColon cancer
dc.subjectJamun-berry
dc.subjectMyrtaceae fruits
dc.subjectJabuticaba
dc.subjectBioactive compounds
dc.titleAntiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family.
dc.typeArtigo de periódico

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