Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.

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dc.contributorMaría M. Bigi, School of Agronomy - UBA; Federico Carlos Blanco, Biotechnology Institute/National Institute of Agricultural Technology - INTA; FLABIO RIBEIRO ARAUJO, CNPGC; Tyler C. Thacker, United States Department of Agriculture/Agricultural Research Service/National Animal Disease Center; Martín J. Zumárraga, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Angel A. Cataldi, Biotechnology Institute/National Institute of Agricultural Technology - INTA; Marcelo A. Soria, School of Agronomy - UBA; Fabiana Bigi, Biotechnology Institute/National Institute of Agricultural Technology - INTA.
dc.creatorBIGI, M. M.
dc.creatorBLANCO, F. C.
dc.creatorARAUJO, F. R.
dc.creatorTHACKER, T. C.
dc.creatorZUMÁRRAGA, M. J.
dc.creatorCATALDI, A. A.
dc.creatorSORIA, M. A.
dc.creatorBIGI, F.
dc.date2018-02-22T00:40:07Z
dc.date2018-02-22T00:40:07Z
dc.date2018-02-21
dc.date2016
dc.date2018-02-22T00:40:07Z
dc.date.accessioned2026-07-07T03:40:22Z
dc.descriptionMycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTCevolved. The genome of M. bovis is over>99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non-synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species-specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia-related genes between M. bovis and M. tuberculosis.
dc.identifierMicrobiology and Immunology, v. 60, n. 8, p. 552-560, August 2016
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1087980
dc.identifier.urihttp://hdl.handle.net/123456789/440397
dc.languageeng
dc.rightsopenAccess
dc.subjectRegulator
dc.subjectPolimorfismo
dc.subjectAnoxia
dc.subjectMycobacterium Bovis
dc.subjectMycobacterium tuberculosis
dc.subjectPolymorphism
dc.titlePolymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis.
dc.typeArtigo de periódico

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