An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle.

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dc.contributorPRISCILA SILVA NEUBERN DE OLIVEIRA, Bolsista/Embrapa Pecuária Sudeste; LUIZ L. COUTINHO, USP; POLYANA C. TIZIOTO, NGS Genomic Solutions; ALINE S. M. CESAR, USP; GABRIELLA B. DE OLIVEIRA, USP; WELLISON J. DA S. DINIZ, UFSCar; ANDRESSA O. DE LIMA, UFSCar; JAMES M. REECY, Iowa State University; GERSON B. MOURÃO, USP; ADHEMAR ZERLOTINI NETO, CNPTIA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
dc.creatorOLIVEIRA, P. S. N. de
dc.creatorCOUTINHO, L. L.
dc.creatorTIZIOTO, P. C.
dc.creatorCESAR, A. S. M.
dc.creatorOLIVEIRA, G. B. de
dc.creatorDINIZ, W, J. da S.
dc.creatorLIMA, A. O. de
dc.creatorREECY, J. M.
dc.creatorMOURÃO, G. B.
dc.creatorZERLOTINI NETO, A.
dc.creatorREGITANO, L. C. de A.
dc.date2018-12-22T23:31:58Z
dc.date2018-12-22T23:31:58Z
dc.date2018-12-20
dc.date2018
dc.date2019-02-05T11:11:11Z
dc.date.accessioned2026-07-07T04:15:45Z
dc.descriptionResidual Feed Intake (RFI) is an economically relevant trait in beef cattle. Among the molecular regulatory mechanisms, microRNAs (miRNAs) are an important dimension in post-transcriptional regulation and have been associated with different biological pathways. Here, we performed differential miRNAs expression and weighted gene co-expression network analyses (WGCNA) to better understand the complex interactions between miRNAs and mRNAs expressed in bovine skeletal muscle and liver. MiRNA and mRNA expression data were obtained from Nelore steers that were genetically divergent for RFI (N = 10 [low RFI or feed efficient]; N = 10 [high RFI or feed inefficient]). Differentially expressed and hub miRNAs such as bta-miR-486, bta-miR-7, bta-miR15a, bta-miR-21, bta-miR 29, btamiR-30b, bta-miR-106b, bta-miR-199a-3p, bta-miR-204, and bta-miR 296 may have a potential role in variation of RFI. Functional enrichment analysis of differentially expressed (DE) miRNA?s target genes and miRNA?mRNA correlated modules revealed that insulin, lipid, immune system, oxidative stress and muscle development signaling pathways might potentially be involved in RFI in this population. Our study identified DE miRNAs, miRNA - mRNA regulatory networks and hub miRNAs related to RFI. These findings suggest a possible role of miRNAs in regulation of RFI, providing new insights into the potential molecular mechanisms that control feed efficiency in Nelore cattle.
dc.descriptionArticle number: 17072. Na publicação: Adhemar Zerlotini, Luciana C. A. Regitano.
dc.identifierScientific Reports, v. 8, p. 1-12, 2018.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1102149
dc.identifier10.1038/s41598-018-35315-5
dc.identifier.urihttp://hdl.handle.net/123456789/455876
dc.languageeng
dc.rightsopenAccess
dc.subjectMicroRNAs
dc.subjectResidual Feed Intake
dc.subjectGado Nelore
dc.subjectBeef cattle
dc.subjectNellore
dc.subjectSkeletal muscle
dc.titleAn integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle.
dc.typeArtigo de periódico

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