Theileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks

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dc.creatorBishop, Richard P.
dc.creatorMusoke, A.J.
dc.creatorMorzaria, S.P.
dc.creatorGardner, M.
dc.creatorNene, Vishvanath M.
dc.date2004-10
dc.date2013-07-03T05:26:03Z
dc.date2013-07-03T05:26:03Z
dc.date.accessioned2026-06-27T16:42:31Z
dc.descriptionTheileria are economically important, intra-cellular protozoa, transmitted by ixodid ticks, which infect wild and domestic ruminants. In the mammalian host, parasites infect leukocytes and erythrocytes. In the arthropod vector they develop in gut epithelial cells and salivary glands. All four intra-cellular stages of Theileria survive free in the cytoplasm. The schizont stages of certain Theileria species induce a unique, cancer-like, phenotype in infected host leukocytes. Theileria undergoes an obligate sexual cycle, involving fusion of gametes in the tick gut, to produce a transiently diploid zygote. The existence of sexual recombination in T. parva has been confirmed in the laboratory, and is presumed to contribute to the extensive polymorphism observed in field isolates. Key parameters in T. parva population dynamics are the relative importance of asymptomatic carrier cattle and animals undergoing severe disease, in transmission of the parasite to ticks, and the extent of transmission by nymphs as compared to adult ticks. Tick populations differ in vector competence for specific T. parva stocks. Recombinant forms of T. parva and T. annulata sporozoite surface antigens induce protection against parasite challenge in cattle. In future, vaccines might be improved by inclusion of tick peptides in multivalent vaccines.
dc.identifierhttps://hdl.handle.net/10568/33095
dc.identifier.urihttp://hdl.handle.net/123456789/131068
dc.languageen
dc.publisherCambridge University Press
dc.rightsLimited Access
dc.sourceParasitology;129(Suppl 1): S271-S283
dc.subjecttheileria parva
dc.subjectruminants
dc.subjectwild animals
dc.subjectdomestic animals
dc.subjectixodidae
dc.subjectprotozoa
dc.subjectsporozoa
dc.subjecttransmissions
dc.subjectrecombinant antigens
dc.subjectvaccines
dc.subjectlife cycle
dc.subjectrhipicephalus appendiculatus
dc.titleTheileria: Intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks
dc.typeJournal Article

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