Nanotoxicological assessment of green-synthesized silver nanoparticles from Brazilian Cerrado plant in a murine model.

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dc.contributorCÍNTHIA CAETANO BONATTO, UNIVERSITY OF BRASILIA (UNB)
dc.contributorIVY GARCEZ REIS, UNIVERSITY OF BRASILIA (UNB)
dc.contributorDALILA JULIANA SILVA RIBEIRO, UNIVERSITY OF BRASILIA (UNB)
dc.contributorRAQUEL DAS NEVES ALMEIDA, UMASS CHAN MEDICAL SCHOOL
dc.contributorRAFAEL CORRÊA, UNIVERSITY OF BRASILIA (UNB)
dc.contributorLIVIA PIMENTEL SANT’ANA DOURADO, UNIVERSITY OF BRASILIA (UNB)
dc.contributorGABRIEL PASQUARELLI-DO-NASCIMENTO, UNIVERSITY OF BRASILIA (UNB)
dc.contributorKELLY GRACE MAGALHÃES, UNIVERSITY OF BRASILIA (UNB)
dc.contributorLUCIANO PAULINO DA SILVA, CENARGEN.
dc.creatorBONATTO, C. C.
dc.creatorREIS, I. G.
dc.creatorRIBEIRO, D. J. S.
dc.creatorALMEIDA, R. das N.
dc.creatorCORRÊA, R.
dc.creatorDOURADO, L. P. S.
dc.creatorPASQUARELLI-DO-NASCIMENTO, G.
dc.creatorMAGALHÃES, K. G.
dc.creatorSILVA, L. P. da
dc.date2025-10-23T12:48:38Z
dc.date2025-10-23T12:48:38Z
dc.date2025-10-23
dc.date2025
dc.date.accessioned2026-07-07T11:56:40Z
dc.descriptionIn recent years, silver nanoparticles (AgNPs) have garnered significant attention due to their potent antimicrobial properties, which hold promise for various applications. However, concerns about their potential toxicity have also emerged, particularly regarding their impact on human and animal health. This study investigates the acute toxicological effects of AgNPs synthesized using a green route with an aqueous extract of a native Cerrado plant (AgNPs-Cb) in mice. Methods: The AgNPs-Cb were intravenously administered at a concentration of 64 µM, and the mice were euthanized after 24 h for the collection of blood and organ samples (liver, spleen, kidneys, and lungs) for hematological, biochemical, and histological analyses. Results: Hematological analysis, including complete blood count (CBC) and differential leukocyte count, showed no statistically significant alterations in the groups treated with AgNPs-Cb, Cb extract, and Ag+, compared with the control group (p < 0.05). Notably, only the Ag+ group exhibited a significant increase in red blood cell count and hematocrit levels, suggesting that the nanoformulation of silver might mitigate the hematological impact seen with free silver ions. Biochemical analyses of liver and kidney function markers also revealed no significant differences across the treatment groups. Conclusions: These findings indicate that AgNPs-Cb may offer a safer alternative for antimicrobial applications, reducing the risk of acute toxicity in mammals while maintaining efficacy against pathogens. Further studies are needed to explore the underlying mechanisms and long-term effects of AgNPs-Cb exposure.
dc.descriptionNa publicação: Luciano Paulino Silva.
dc.identifierPharmaceuticals, v. 18, n. 7, 993, 2025.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1180502
dc.identifierhttps://doi.org/10.3390/ph18070993
dc.identifier.urihttp://hdl.handle.net/123456789/518444
dc.languageeng
dc.rightsopenAccess
dc.subjectAgNPs
dc.subjectNanosafety
dc.subjectGreen synthesis
dc.subjectHematological analysis
dc.subjectBiochemical analysis
dc.subjectHistological analysis
dc.subjectCaryocar Brasiliense
dc.subjectCerrado
dc.titleNanotoxicological assessment of green-synthesized silver nanoparticles from Brazilian Cerrado plant in a murine model.
dc.typeArtigo de periódico

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