Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.)

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dc.creatorPanda, S.K.
dc.creatorCastro, A.H.F.
dc.creatorJouneghani, R.S.
dc.creatorLeyssen, P.
dc.creatorNeyts, J.
dc.creatorSwennen, Rony L.
dc.creatorLuyten, W.
dc.date2020
dc.date2020-09-21T10:06:07Z
dc.date2020-09-21T10:06:07Z
dc.date.accessioned2026-06-27T13:22:05Z
dc.descriptionChikungunya and yellow fever virus cause vector-borne viral diseases in humans. There is currently no specific antiviral drug for either of these diseases. Banana plants are used in traditional medicine for treating viral diseases such as measles and chickenpox. Therefore, we tested selected banana cultivars for their antiviral but also cytotoxic properties. Different parts such as leaf, pseudostem and corm, collected separately and extracted with four different solvents (hexane, acetone, ethanol, and water), were tested for in vitro antiviral activity against Chikungunya virus (CHIKV), enterovirus 71 (EV71), and yellow fever virus (YFV). Extracts prepared with acetone and ethanol from leaf parts of several cultivars exhibited strong (EC50 around 10 μg/mL) anti-CHIKV activity. Interestingly, none of the banana plant extracts (concentration 1–100 µg/mL) were active against EV71. Activity against YFV was restricted to two cultivars: Namwa Khom–Pseudostem–Ethanol (5.9 ± 5.4), Namwa Khom–Corm–Ethanol (0.79 ± 0.1) and Fougamou–Corm–Acetone (2.5 ± 1.5). In most cases, the cytotoxic activity of the extracts was generally 5- to 10-fold lower than the antiviral activity, suggesting a reasonable therapeutic window.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/109550
dc.identifier.urihttp://hdl.handle.net/123456789/57166
dc.languageen
dc.publisherMDPI
dc.rightsOpen Access
dc.sourcePanda, S.K., Castro, A.H.F., Jouneghani, R.S., Leyssen, P., Neyts, J., Swennen, R. & Luyten, W. (2020). Antiviral and cytotoxic activity of different plant parts of banana (Musa spp.). Viruses, 12(5), 549: 1-17.
dc.subjectbananas
dc.subjectchikungunya virus
dc.subjectcytotoxicity
dc.subjectenterovirus
dc.subjectplant diseases
dc.subjectcultivars
dc.subjectyellow fever
dc.subjectantiviral agents
dc.subjectvirology
dc.subjectinfectious diseases
dc.titleAntiviral and cytotoxic activity of different plant parts of banana (Musa spp.)
dc.typeJournal Article

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