African suid genomes provide insights into the local adaptation to diverse African environments

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dc.creatorHai-Bing Xie
dc.creatorChen Yan
dc.creatorAdeola, A.C.
dc.creatorKun Wang
dc.creatorCui-Ping Huang
dc.creatorMing-Min Xu
dc.creatorQiang Qiu
dc.creatorXue Yin
dc.creatorChen-Yu Fan
dc.creatorYun-Fei Ma
dc.creatorTing-Ting Yin
dc.creatorYun Gao
dc.creatorJia-Kun Deng
dc.creatorOkeyoyin, A.O.
dc.creatorOluwole, O.O.
dc.creatorOmotosho, O.
dc.creatorOkoro, V.M.O.
dc.creatorOmitogun, O.G.
dc.creatorDawuda, P.M.
dc.creatorOlaogun, S.C.
dc.creatorNneji, L.M.
dc.creatorAyoola, A.O.
dc.creatorSanke, O.J.
dc.creatorLuka, P.D.
dc.creatorOkoth, Edward A.
dc.creatorLekolool, I.
dc.creatorMijele, D.
dc.creatorBishop, Richard P.
dc.creatorJianlin Han
dc.creatorWen Wang
dc.creatorMin-Sheng Peng
dc.creatorYa-Ping Zhang
dc.date2022-12-05
dc.date2022-11-28T10:40:58Z
dc.date2022-11-28T10:40:58Z
dc.date.accessioned2026-06-27T16:39:25Z
dc.descriptionAfrican wild suids consist of several endemic species that represent ancient members of the family Suidae and have colonized diverse habitats on the African continent. However, limited genomic resources for African wild suids hinder our understanding of their evolution and genetic diversity. In this study, we assembled high-quality genomes of a common warthog (Phacochoerus africanus), a red river hog (Potamochoerus porcus), as well as an East Asian Diannan small-ear pig (Sus scrofa). Phylogenetic analysis showed that common warthog and red river hog diverged from their common ancestor around the Miocene/Pliocene boundary, putatively predating their entry into Africa. We detected species-specific selective signals associated with sensory perception and interferon signaling pathways in common warthog and red river hog, respectively, which contributed to their local adaptation to savannah and tropical rainforest environments, respectively. The structural variation and evolving signals in genes involved in T-cell immunity, viral infection, and lymphoid development were identified in their ancestral lineage. Our results provide new insights into the evolutionary histories and divergent genetic adaptations of African suids.
dc.identifierhttps://hdl.handle.net/10568/125687
dc.identifier.urihttp://hdl.handle.net/123456789/129483
dc.languageen
dc.publisherOxford University Press
dc.rightsOpen Access
dc.sourceXie, H.-B., Yan, C., Adeola, A.C., Wang, K., Huang, C.-P., Xu, M.-M., Qiu, Q., Yin, X., Fan, C.-Y., Ma, Y.-F., Yin, T.-T., Gao, Y., Deng, J.-K., Okeyoyin, A.O., Oluwole, O.O., Omotosho, O., Okoro, V.M.O., Omitogun, O.G., Dawuda, P.M., Olaogun, S.C., Nneji, L.M., Ayoola, A.O., Sanke, O.J., Luka, P.D., Okoth, E., Lekolool, I., Mijele, D., Bishop, R.P., Han, J., Wang, W., Peng, M.-S. and Zhang, Y.-P. 2022. African suid genomes provide insights into the local adaptation to diverse African environments. Molecular Biology and Evolution 39(12): msac256.
dc.subjectsuidae
dc.subjectswine
dc.subjectpig breeds
dc.subjectgenomes
dc.subjectafrican swine fever
dc.subjectgenetics
dc.subjectmolecular biology
dc.titleAfrican suid genomes provide insights into the local adaptation to diverse African environments
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)