Developing improved inoculants through genome editing of diazotrophic bacteria for cereals: is this the right time for Brazil?

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dc.contributorPAULO IVAN FERNANDES JUNIOR, CPATSA; MARIA CAROLINA QUECINE, UNIVERSITY OF SÃO PAULO; SYLVIA MORAIS DE SOUSA TINOCO, CNPMS.
dc.creatorFERNANDES JUNIOR, P. I.
dc.creatorQUECINE, M. C.
dc.creatorSOUSA, S. M. de
dc.date2026-03-13T13:55:07Z
dc.date2026-03-13T13:55:07Z
dc.date2026-03-13
dc.date2026
dc.date.accessioned2026-07-07T06:01:41Z
dc.descriptionMicrobial inoculants for grasses containing Azospirillum brasilense have been commercially available in Brazil for 15 years, achieving great success and being applied in more than one-third of the Brazilian maize fields. However, these inoculant technologies could be improved by applying modern genomic editing tools, leading to the development of remodelled strains with increased diazotrophic ability. The most successful example of this kind of inoculant development is provided by the Pivot Bio company in the United States, which has engineered diazotrophic Enterobacteriaceae used in products currently widespread throughout the US market. Pivot Bio had applied to commercialize inoculants with their remodeled strains in Brazil, with a positive evaluation from the National Technical Commission on Biosafety (CTNBio), indicating their legal feasibility. Brazilian researchers working in this field have several advantages that will enable them to move into the new generation of inoculants: we have tremendous microbial biodiversity, technically skilled teams, and a partially favorable regulatory framework. We should move towards these enhanced inoculants to capitalize on our advantages, develop a new, genuine Brazilian technology, and achieve yield increases, cost reductions, and improved sustainability in Brazilian agricultural fields.
dc.descriptionOn-line.
dc.identifierBrazilian Journal of Microbiology, v. 57, 73, 2026.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1185383
dc.identifierhttps://doi.org/10.1007/s42770-025-01855
dc.identifier.urihttp://hdl.handle.net/123456789/504719
dc.languageeng
dc.rightsopenAccess
dc.subjectExcretadores de amônio
dc.subjectFixação biológica de nitrogênio
dc.subjectEdição genética
dc.subjectBactérias diazotróficas
dc.subjectBactéria
dc.subjectSolo
dc.subjectNitrogenase
dc.subjectCereal
dc.subjectMilho
dc.subjectAzospirillum brasilense
dc.titleDeveloping improved inoculants through genome editing of diazotrophic bacteria for cereals: is this the right time for Brazil?
dc.typeArtigo de periódico

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