The genome of the blood fluke Schistosoma mansoni

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dc.creatorBerriman, M.
dc.creatorHaas, B.J.
dc.creatorLoVerde, P.T.
dc.creatorWilson, R.A.
dc.creatorDillon, G.P.
dc.creatorCerqueira, G.C.
dc.creatorMashiyama, S.T.
dc.creatorAl-Lazikani, B.
dc.creatorAndrade, L.F.
dc.creatorAshton, P.D.
dc.creatorAslett, M.A.
dc.creatorBartholomeu, D.C.
dc.creatorBlandin, G.
dc.creatorCaffrey, C.R.
dc.creatorCoghlan, A.
dc.creatorCoulson, R.
dc.creatorDay, T.A.
dc.creatorDelcher, A.
dc.creatorDeMarco, R.
dc.creatorDjikeng, Appolinaire
dc.creatorEyre, T.
dc.creatorGamble, J.A.
dc.creatorGhedin, E.
dc.creatorGu, Y.
dc.creatorHertz-Fowler, C.
dc.creatorHirai, H.
dc.creatorHirai, Y.
dc.creatorHouston, R.
dc.creatorIvens, A.
dc.creatorJohnston, D.A.
dc.creatorLacerda, D.
dc.creatorMacedo, C.D.
dc.creatorMcVeigh, P.
dc.creatorNing, Z.
dc.creatorOliveira, G.
dc.creatorOverington, J.P.
dc.creatorParkhill, J.
dc.creatorPertea, M.
dc.creatorPierce, R.J.
dc.creatorProtasio, A.V.
dc.creatorQuail, M.A.
dc.creatorRajandream, M.A.
dc.creatorRogers, J.
dc.creatorSajid, M.
dc.creatorSalzberg, S.L.
dc.creatorStanke, M.
dc.creatorTivey, A.R.
dc.creatorWhite, O.
dc.creatorWilliams, D.L.
dc.creatorWortman, Jennifer R.
dc.creatorWu, W.
dc.creatorZamanian, M.
dc.creatorZerlotini, A.
dc.creatorFraser-Liggett, C.M.
dc.creatorBarrell, B.G.
dc.creatorEl-Sayed, N.M.
dc.date2009-07
dc.date2015-09-30T10:55:55Z
dc.date2015-09-30T10:55:55Z
dc.date.accessioned2026-06-27T16:36:23Z
dc.descriptionSchistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. Here we present analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and new families of micro-exon genes that undergo frequent alternative splicing. As the first sequenced flatworm, and a representative of the Lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, and the identification of membrane receptors, ion channels and more than 300 proteases provide new insights into the biology of the life cycle and new targets. Bioinformatics approaches have identified metabolic chokepoints, and a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease.
dc.identifierhttps://hdl.handle.net/10568/68366
dc.identifier.urihttp://hdl.handle.net/123456789/127936
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceBerriman, M., Haas, B.J., LoVerde, P.T., Wilson, R.A., Dillon, G.P., Cerqueira, G.C., Mashiyama, S.T., Al-Lazikani, B., Andrade, L.F., Ashton, P.D., Aslett, M.A., Bartholomeu, D.C., Blandin, G., Caffrey, C.R., Coghlan, A., Coulson, R., Day, T.A., Delcher, A., DeMarco, R., Djikeng, A., Eyre, T., Gamble, J.A., Ghedin, E., Gu, Y., Hertz-Fowler, C., Hirai, H., Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning, Z., Oliveira, G., Overington, J.P., Parkhill, J., Pertea, M., Pierce, R.J., Protasio, A.V., Quail, M.A., Rajandream, M.A., Rogers, J., Sajid, M., Salzberg, S.L., Stanke, M., Tivey, A.R., White, O., Williams, D.L., Wortman, J., Wu, W., Zamanian, M., Zerlotini, A., Fraser-Liggett, C.M., Barrell, B.G. and El-Sayed, N.M. 2009. The genome of the blood fluke Schistosoma mansoni. Nature 460:352-358.
dc.subjectschistosoma
dc.subjecthealth
dc.titleThe genome of the blood fluke Schistosoma mansoni
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)