Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice

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dc.creatorDe Vleesschauwer, David
dc.creatorVan Buyten, Evelien
dc.creatorSatoh, Kouji
dc.creatorBalidion, Johny
dc.creatorMauleon, Ramil
dc.creatorChoi, Il-Ryong
dc.creatorVera Cruz, Casiana
dc.creatorKikuchi, Shoshi
dc.creatorHöfte, Monica
dc.date2012-04-02
dc.date2024-12-19T12:55:30Z
dc.date2024-12-19T12:55:30Z
dc.date.accessioned2026-06-27T04:07:51Z
dc.descriptionBrassinosteroids (BRs) are a unique class of plant steroid hormones that orchestrate myriad growth and developmental processes. Although BRs have long been known to protect plants from a suite of biotic and abiotic stresses, our understanding of the underlying molecular mechanisms is still rudimentary. Aiming to further decipher the molecular logic of BR-modulated immunity, we have examined the dynamics and impact of BRs during infection of rice (Oryza sativa) with the root oomycete Pythium graminicola. Challenging the prevailing view that BRs positively regulate plant innate immunity, we show that P. graminicola exploits BRs as virulence factors and hijacks the rice BR machinery to inflict disease. Moreover, we demonstrate that this immune-suppressive effect of BRs is due, at least in part, to negative cross talk with salicylic acid (SA) and gibberellic acid (GA) pathways. BR-mediated suppression of SA defenses occurred downstream of SA biosynthesis, but upstream of the master defense regulators NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and OsWRKY45. In contrast, BR alleviated GA-directed immune responses by interfering at multiple levels with GA metabolism, resulting in indirect stabilization of the DELLA protein and central GA repressor SLENDER RICE1 (SLR1). Collectively, these data favor a model whereby P. graminicola coopts the plant BR pathway as a decoy to antagonize effectual SA- and GA-mediated defenses. Our results highlight the importance of BRs in modulating plant immunity and uncover pathogen-mediated manipulation of plant steroid homeostasis as a core virulence strategy.
dc.identifierhttps://hdl.handle.net/10568/165799
dc.identifier.urihttp://hdl.handle.net/123456789/22531
dc.languageen
dc.publisherOxford University Press
dc.rightsOpen Access
dc.sourceDe Vleesschauwer, D., Van Buyten, E., Satoh, K., Balidion, J., Mauleon, R., Choi, Il-Ryong, Vera-Cruz, C., Kikuchi, S. and Höfte, M. 2012. Brassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice. Plant Physiology, Volume 158, no. 4, pages 1833-1846, ill. Ref. Apr.
dc.subjectbrassinosteroids
dc.subjectdisease resistance
dc.subjectfungi
dc.subjectgibberellic acid
dc.subjectpathogens
dc.subjectplant growth substances
dc.subjectplant pathogenic fungi
dc.subjectroots
dc.subjectsalicylic acid
dc.subjectvirulence
dc.titleBrassinosteroids antagonize gibberellin- and salicylate-mediated root immunity in rice
dc.typeJournal Article

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Instituto Internacional de Investigación del Arroz (IRRI)