Segmental duplications drive the evolution of accessory regions in a major crop pathogen

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dc.creatorvan Westerhoven, A.C.
dc.creatorAguilera-Galvez, C.
dc.creatorNakasato-Tagami, G.
dc.creatorShi-Kunne, X.
dc.creatorde la Parte, E.M.
dc.creatorChavarro-Carrero, E.
dc.creatorMeijer, H.J.G.
dc.creatorFeurtey, A.
dc.creatorMaryani, N.
dc.creatorOrdonez, N.
dc.creatorSchneiders, H.
dc.creatorNijbroek, K.
dc.creatorWittenberg, A.H.J.
dc.creatorHofstede, R.
dc.creatorGarcia-Bastidas, F.
dc.creatorSorensen, A.
dc.creatorSwennen, R.
dc.creatorDrenth, A.
dc.creatorStukenbrock, E.H.
dc.creatorKema, G.H.J.
dc.creatorSeidl, M.F.
dc.date2024-04
dc.date2024-07-12T09:07:13Z
dc.date2024-07-12T09:07:13Z
dc.date.accessioned2026-06-27T16:02:50Z
dc.descriptionMany pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum has such ARs, often spanning entire chromosomes. The presence of specific ARs influences the host range, and horizontal transfer of ARs can modify the pathogenicity of the receiving strain. However, how these ARs evolve in strains that infect the same host remains largely unknown. We defined the pan-genome of 69 diverse F. oxysporum strains that cause Fusarium wilt of banana, a significant constraint to global banana production, and analyzed the diversity and evolution of the ARs. Accessory regions in F. oxysporum strains infecting the same banana cultivar are highly diverse, and we could not identify any shared genomic regions and in planta-induced effectors. We demonstrate that segmental duplications drive the evolution of ARs. Furthermore, we show that recent segmental duplications specifically in accessory chromosomes cause the expansion of ARs in F. oxysporum. Taken together, we conclude that extensive recent duplications drive the evolution of ARs in F. oxysporum, which contribute to the evolution of virulence.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/149052
dc.identifier.urihttp://hdl.handle.net/123456789/120965
dc.languageen
dc.publisherWiley
dc.rightsOpen Access
dc.sourcevan Westerhoven, A. C., Aguilera‐Galvez, C., Nakasato‐Tagami, G., Shi‐Kunne, X., Martinez de la Parte, E., Chavarro‐Carrero, E., ... & Seidl, M. F. (2024). Segmental duplications drive the evolution of accessory regions in a major crop pathogen. New Phytologist, 242(2), 610-625.
dc.subjectfusarium oxysporum
dc.subjectgenomes
dc.subjectpathogens
dc.subjectevolution
dc.titleSegmental duplications drive the evolution of accessory regions in a major crop pathogen
dc.typeJournal Article

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Instituto Internacional de Agricultura Tropical (IITA)