Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells

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dc.creatorLambson, B.
dc.creatorNene, Vishvanath M.
dc.creatorObura, M.
dc.creatorShah, Tushaar
dc.creatorPandit, P.
dc.creatorOle-MoiYoi, O.K.
dc.creatorDelroux, K.
dc.creatorWelburn, S.C.
dc.creatorSkilton, Robert A.
dc.creatorVilliers, Etienne P. de
dc.creatorBishop, Richard P.
dc.date2005-08
dc.date2012-07-09T05:47:05Z
dc.date2012-07-09T05:47:05Z
dc.date.accessioned2026-06-27T16:54:03Z
dc.descriptionIxodid ticks manipulate mammalian host pathways by secreting molecules from salivary glands. Novel cDNAs containing functional secretion signals were isolated from ixodid tick salivary glands using a signal sequence trap. Only 15/61 Rhipicephalus appendiculatus and 1/7 Amblyomma variegatum cDNAs had significant identity (< 1e-15) to previously identified sequences. Polypeptides that may interact with host pathways included a kinase inhibitor. Two proteins encoded homologues of the yolk protein vitellogenin and seventeen contained glycine-rich motifs. Four proteins without sequence matches had conserved structural folds, identified using a Threading algorithm. Predicted secretion signals were between fifteen and fifty-seven amino acids long. Four homologous polymorphic proteins contained conserved (26/27 residues) signal peptides. Ten functional tick secretion signals could not be unambiguously identified using predictive algorithms.
dc.identifierhttps://hdl.handle.net/10568/21174
dc.identifier.urihttp://hdl.handle.net/123456789/136542
dc.languageen
dc.publisherWiley
dc.rightsLimited Access
dc.sourceLambson, B., Nene, V., Obura, M., Shah, T., Pandit, P., Ole‐MoiYoi, O., Delroux, K., Welburn, S., Skilton, R., De Villiers, E., & Bishop, R. (2005). Identification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells. Insect Molecular Biology, 14(4), 403–414. Portico. https://doi.org/10.1111/j.1365-2583.2005.00571.x
dc.subjectinsects
dc.subjectticks
dc.subjectixodidae
dc.subjectmetastigmata
dc.subjectsalivary glands [exocrine glands]
dc.subjectsecretion
dc.subjectmammals
dc.subjectcells
dc.subjectdna
dc.subjectrhipicephalus appendiculatus
dc.subjectnucleotide sequence
dc.subjectamblyomma variegatum
dc.subjectpolymorphism
dc.subjectproteins
dc.titleIdentification of candidate sialome components expressed in ixodid tick salivary glands using secretion signal complementation in mammalian cells
dc.typeJournal Article

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