Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631

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dc.creatorSironi, L.
dc.creatorWilliams, J.L.
dc.creatorMoreno Martin, A.M.
dc.creatorRamelli, P.
dc.creatorStella, A.
dc.creatorWeigend, S.
dc.creatorLombardi, G.
dc.creatorCordioli, P.
dc.creatorMariani, P.
dc.creatorHan Jianlin
dc.date2008-10
dc.date2010-05-11T17:34:13Z
dc.date2010-05-11T17:34:13Z
dc.date.accessioned2026-06-27T16:45:43Z
dc.descriptionFive chicken lines were experimentally infected with a HPAI H7N1 virus, to examine the variation in susceptibility to infection. Three lines showed high susceptibility to the virus, while two showed some resistance, with 7 out of 20, and 11 out of 15 birds, respectively, remaining healthy and surviving the experimental infection. Genotyping for the G/A polymorphism at position 2032 of Mx cDNA showed that one line was fixed for the G allele, and two were segregating for A and G alleles. Birds in the other two lines were selected to be fixed for the A allele. Statistical analyses indicated that the Mx genotype did not affect the clinical status or the time course of infection after viral inoculation.
dc.identifierhttps://hdl.handle.net/10568/1501
dc.identifier.urihttp://hdl.handle.net/123456789/132448
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceSironi, L.; Williams, J.L.; Moreno-Martin, A.M.; Ramelli, P.; Stella, A.; Jianlin, H.; Weigend, S.; Lombardi, G.; Cordioli, P.; Mariani, P. 2008. Susceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631. Virology 380(1):52-158.
dc.subjectanimal diseases
dc.subjectdisease control
dc.subjectchickens
dc.titleSusceptibility of different chicken lines to H7N1 highly pathogenic avian influenza virus and the role of Mx gene polymorphism coding amino acid position 631
dc.typeJournal Article

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