Selecting oocyte donors based on anti-Müllerian hormone (AMH) concentrations: a critical analysis of using cutoff values as exclusion criterion for an in vitro embryo production program in Gir cattle.

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dc.contributorLUIZ FERNANDO RODRIGUES FERES, UNIVERSIDADE JOSÉ DO ROSÁRIO VELLANO; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; MILLER PEREIRA PALHAO, UNIVERSIDADE FEDERAL DE LAVRAS; LIVIA LOIOLA DOS SANTOS, UNIVERSIDADE FEDERAL DE MINAS GERAIS; LUIZ FRANCISCO MACHADO PFEIFER, CPAF-RO; CARLOS ANTÔNIO DE CARVALHO FERNANDES, UNIVERSIDADE JOSÉ DO ROSÁRIO VELLANO; JOAO HENRIQUE MOREIRA VIANA, CENARGEN.
dc.creatorFERES, L. F. R.
dc.creatorSIQUEIRA, L. G. B.
dc.creatorPALHAO, M. P.
dc.creatorSANTOS, L. L. dos
dc.creatorPFEIFER, L. F. M.
dc.creatorFERNANDES, C. A. de C.
dc.creatorVIANA, J. H. M.
dc.date2024-05-28T15:52:32Z
dc.date2024-05-28T15:52:32Z
dc.date2024-05-28
dc.date2024
dc.date.accessioned2026-07-07T03:56:16Z
dc.descriptionThe aims of this study were to determine anti-müllerian hormone (AMH) cutoff values for selecting Gir (Bos taurus indicus) oocyte donors and estimate the impact of using AMH concentrations as a selection criterion. In Exp. 1, Gir heifers (n=120) were sampled for AMH analysis and submitted to ovum pick-up and in vitro embryo production (OPU-IVEP). AMH cutoff values were calculated using ROC analysis or, alternatively, by the successive exclusion of heifers with the lowest AMH values. The correlations between AMH and OPU-IVEP outcomes were significant (P<0.001), though low or moderate (r= 0.34–0.52). We estimated an improvement (P<0.05) after the use of AMH cutoff values to select donors of +15.3% for total oocyes, +19.4% for viable COC, and +23.4% for blastocysts. This selection pressure, however, led to the exclusion of 32.8%, 37.9%, and 50.0% of the initial potential donors, respectively. In Exp. 2, we analyzed data from OPU-IVEP sessions of 658 Gir donors with known genomic values for predicted transmitting ability for milk (GPTAm) and age at first calving (GPTAafc). The selection based on the number of oocytes recovered had no effect (P>0.05) on the average GPTAm nor GPTAafc values of the remaining donors. In summary, plasma AMH ≥700 pg/mL is a cutoff value that can be used to select Gir heifers with a greater potential as oocyte donors. Nevertheless, this selection leads to the exclusion of up to 50% of potential donors. Finally, exclusion of poor responders had no effect on mean genomic estimates for milk production or age at first calving in the selected subset of donors.
dc.identifierAnimal Reproduction Science, v. 266, 107491, May 2024.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1164560
dc.identifierhttps://doi.org/10.1016/j.anireprosci.2024.107491
dc.identifier.urihttp://hdl.handle.net/123456789/447918
dc.languageeng
dc.rightsopenAccess
dc.subjectDoadoras de oócito
dc.subjectOocyte donors
dc.subjectValor de corte
dc.subjectCutoff value
dc.subjectAnti-Müllerian hormone (AMH)
dc.subjectFazendas do Basa
dc.subjectLeopoldina (MG)
dc.subjectMinas Gerais
dc.subjectReprodução Animal
dc.subjectFertilidade Animal
dc.subjectHormônio Animal
dc.subjectGado Gir
dc.subjectVaca
dc.subjectAnimal reproduction
dc.subjectAnimal fertility
dc.subjectHormones
dc.subjectGir (cattle breed)
dc.subjectCows
dc.titleSelecting oocyte donors based on anti-Müllerian hormone (AMH) concentrations: a critical analysis of using cutoff values as exclusion criterion for an in vitro embryo production program in Gir cattle.
dc.typeArtigo de periódico

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