Small ruminant pasteurellosis in Tigray region, Ethiopia: Marked serotype diversity may affect vaccine efficacy

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dc.creatorBerhe, Kahsay
dc.creatorWeldeselassie, G.
dc.creatorBettridge, Judy M.
dc.creatorChristley, Robert M.
dc.creatorAbdi, R.D.
dc.date2017-05
dc.date2018-12-26T06:17:36Z
dc.date2018-12-26T06:17:36Z
dc.date.accessioned2026-06-27T16:42:33Z
dc.descriptionThe aim of this study was to investigate the prevalentBibersteinia, MannheimiaandPasteurellaserotypes, risk factors and degree of serotype co-infections in sheep and goats in the Tigray region of Ethiopia. Serum was collected from 384 sheep and goats from the Tanqua-Abergelle district of Tigray region using cross-sectional random sampling. An indirect haemagglutination test was used for serotyping. Risk factors for infections were evaluated by logistic regression. Potential clustering of multiple serotypes within individual animals due to common risk factors was evaluated by redundancy analysis. Eight serotypes were identified: all studied animals were serologically positive for at least one serotype. Overall, 355 (92·45%) of the animals were infected by four or more serotypes. Of the five risk factors studied, peasant association (PA), animal species, age (serotype A1), and bodyweight (serotype T15) were significantly associated with infection, but sex was not significant. Only PA explained a significant proportion of the variation (adjustedR2= 0·16) in the serological responses. After the effect of PA was accounted for, T3 and T4; A7 andPasteurella multocidaA; and A7 and T10 were positively correlated for co-infection, while T4 and T10 were less likely to be found within the same animal. Diverse serotypes were circulating in the Tigray region and could be a challenge in selecting serotypes for vaccine.
dc.identifierhttps://hdl.handle.net/10568/98874
dc.identifier.urihttp://hdl.handle.net/123456789/131083
dc.languageen
dc.publisherCambridge University Press
dc.rightsOpen Access
dc.sourceBerhe, K., Weldeselassie, G., Bettridge, J., Christley, R.M. and Abdi, R.D. 2017. Small ruminant pasteurellosis in Tigray region, Ethiopia: Marked serotype diversity may affect vaccine efficacy. Epidemiology and Infection 145(7):1326-1338.
dc.subjectsmall ruminants
dc.subjectgoats
dc.subjectsheep
dc.subjectanimal diseases
dc.subjectgenetics
dc.subjectvaccines
dc.titleSmall ruminant pasteurellosis in Tigray region, Ethiopia: Marked serotype diversity may affect vaccine efficacy
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)