Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep.

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dc.contributorSIMONE CRISTINA MEO NICIURA, CPPSE; TAINÃ FIGUEIREDO CARDOSO; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; CINTIA HIROMI OKINO, CPPSE; BRUNO GABRIEL ANDRADE, Munster Technological University, Cork, Ireland; MAGDA VIEIRA BENAVIDES, CPPSUL; ANA CAROLINA DE SOUZA CHAGAS, CPPSE; SERGIO NOVITA ESTEVES, CPPSE; ALESSANDRO PELEGRINE MINHO, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; CEDRIC GONDRO, Michigan State University, East Lansing, MI, USA.
dc.creatorNICIURA, S. C. M.
dc.creatorCARDOSO, T. F.
dc.creatorIBELLI, A. M. G.
dc.creatorOKINO, C. H.
dc.creatorANDRADE, B. G.
dc.creatorBENAVIDES, M. V.
dc.creatorCHAGAS, A. C. de S.
dc.creatorESTEVES, S. N.
dc.creatorMINHO, A. P.
dc.creatorREGITANO, L. C. de A.
dc.creatorGONDRO, C.
dc.date2024-03-05T17:32:27Z
dc.date2024-03-05T17:32:27Z
dc.date2024-03-05
dc.date2024
dc.date.accessioned2026-07-07T05:33:25Z
dc.descriptionThe integration of molecular data from hosts, parasites, and microbiota can enhance our understanding of the complex biological interactions underlying the resistance of hosts to parasites. Haemonchus contortus, the predominant sheep gastrointestinal parasite species in the tropics, causes significant production and economic losses, which are further compounded by the diminishing efficiency of chemical control owing to anthelmintic resistance. Knowledge of how the host responds to infection and how the parasite, in combination with microbiota, modulates host immunity can guide selection decisions to breed animals with improved parasite resistance. This understanding will help refine management practices and advance the development of new therapeutics for long-term helminth control.
dc.identifierParasites & Vectors, v. 17, n. 102, 2024.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1162588
dc.identifier10.1186/s13071-024-06205-9
dc.identifier.urihttp://hdl.handle.net/123456789/494887
dc.languageeng
dc.rightsopenAccess
dc.subjectGWAS
dc.subjectRNA seq
dc.subject16S rDNA sequencing
dc.subjectEQTL
dc.subjectParasite resistance
dc.subjectBarber's pole worm
dc.titleMulti-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus. in sheep.
dc.typeArtigo de periódico

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