Lysine biofortification of crops to promote sustained human health in the 21st century

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dc.creatorYang, Qingqing
dc.creatorZhao, Dongsheng
dc.creatorZhang, Chuangquan
dc.creatorSreenivasulu, Nese
dc.creatorSun, Samuel Sai-Ming
dc.creatorLiu, Qiaoquan
dc.date2022-03-02
dc.date2024-12-19T12:53:32Z
dc.date2024-12-19T12:53:32Z
dc.date.accessioned2026-06-27T04:13:41Z
dc.descriptionCrop biofortification is pivotal in preventing malnutrition, with lysine considered the main limiting essential amino acid (EAA) required to maintain human health. Lysine deficiency is predominant in developing countries where cereal crops are the staple food, highlighting the need for efforts aimed at enriching the staple diet through lysine biofortification. Successful modification of aspartate kinase (AK) and dihydrodipicolinate synthase (DHDPS) feedback inhibition has been used to enrich lysine in transgenic rice plants without yield penalty, while increases in the lysine content of quality protein maize have been achieved via marker-assisted selection. Here, we reviewed the lysine metabolic pathway and proposed the use of metabolic engineering targets as the preferred option for fortification of lysine in crops. Use of gene editing technologies to translate the findings and engineer lysine catabolism is thus a pioneering step forward.
dc.identifierhttps://hdl.handle.net/10568/164172
dc.identifier.urihttp://hdl.handle.net/123456789/25800
dc.languageen
dc.publisherOxford University Press
dc.sourceYang, Qingqing, Zhao, Dongsheng, Zhang, Chuangquan, Sreenivasulu, N., Sun, S.S.-M. and Liu, Qiaoquan. 2022. Lysine biofortification of crops to promote sustained human health in the 21st century. Journal of Experimental Botany, erab482.
dc.subjectphysiology
dc.subjectplant science
dc.titleLysine biofortification of crops to promote sustained human health in the 21st century
dc.typeJournal Article

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Instituto Internacional de Investigación del Arroz (IRRI)