Insertion/deletion polymorphism of the angiotensinconverting enzyme gene and the risk of hypertension among residents of two cities, SouthSouth Nigeria
| dc.creator | Kooffreh, M.E. | |
| dc.creator | Anumudu, C.I. | |
| dc.creator | Kumar, P. Lava | |
| dc.date | 2014 | |
| dc.date | 2016-07-11T08:41:52Z | |
| dc.date | 2016-07-11T08:41:52Z | |
| dc.date.accessioned | 2026-06-27T15:58:54Z | |
| dc.description | Background: Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. This study was designed to determine the frequency of the I/D polymorphism of the angiotensin-converting enzyme gene and its association with hypertension in a sample population of Calabar and Uyo, South-South Nigeria. Materials and Methods: A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls, were randomly recruited from hypertension clinics and the general population. The I/D polymorphism was investigated using polymerase chain reaction. Multiple regression and odds ratio (OR) was applied to test whether the ID genotypes were predictors of hypertension. Results: The I/D genotype frequencies were 73(12%), 262(43%) and 277(45%); 74(12%), 303(50%) and 235(38%) for the II, ID, DD genotype in patient and control groups, respectively. A higher frequency of the ID genotype was observed in controls of which 208(61%) were females. By multiple regression analysis, age was a predictor for SBP in patients, r = 0.596, and DBP in controls, r = 0.555. Gender, Body mass index, I/D genotypes were not significant predictors for hypertension but the I/D polymorpism was associated with an increased risk for hypertension with an OR of 1.15 95%CI (0.924-1.456). Conclusion: The I/D polymorphism of the angiotensin-converting enzyme gene was a risk factor for hypertension in the sample population of Calabar and Uyo. This research will form baseline information for subsequent molecular studies in this population. Key Words: Angiotensin-converting enzyme gene, frequency | |
| dc.format | application/pdf | |
| dc.identifier | https://hdl.handle.net/10568/76088 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/119159 | |
| dc.language | en | |
| dc.publisher | Medknow | |
| dc.rights | Open Access | |
| dc.source | Kooffreh, M. E., Anumudu, C. I. & Kumar, P. L. (2014). Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the risk of hypertension among residents of two cities, South-South Nigeria. Advanced biomedical research, 3. | |
| dc.subject | angiotensin | |
| dc.subject | hypertension | |
| dc.subject | genotypes | |
| dc.subject | polymorphism | |
| dc.title | Insertion/deletion polymorphism of the angiotensinconverting enzyme gene and the risk of hypertension among residents of two cities, SouthSouth Nigeria | |
| dc.type | Journal Article |