Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX

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dc.creatorRathakrishnan, A.
dc.creatorHemmink, Johanneke D.
dc.creatorPetrovan, V.
dc.creatorReis, A.L.
dc.creatorDixon, L.K.
dc.date2025-12-31
dc.date2025-05-13T06:01:23Z
dc.date2025-05-13T06:01:23Z
dc.date.accessioned2026-06-27T17:09:11Z
dc.descriptionAfrican swine fever virus originated in a wildlife cycle in East Africa and spread to domestic pigs. At least twenty-three genotypes are present in Africa whereas only genotypes I and II have spread to other continents. Vaccine development has been directed mainly to genotype II. The ability of genotype II vaccines to induce cross-protection against other genotypes is unknown. Here, we compared cross-protection induced in pigs by an attenuated multiple gene-deleted genotype II modified live vaccine candidate against challenge with different genotypes. Protection against homologous virulent genotype II virus was 100%. Cross-protection against virulent genotype I virus varied between 57 and 71%. However, no protection was achieved against genotype IX challenge. The results indicate potential for use of vaccines in regions where genotypes I and II are circulating.
dc.identifierhttps://hdl.handle.net/10568/174531
dc.identifier.urihttp://hdl.handle.net/123456789/143767
dc.languageen
dc.publisherInforma UK Limited
dc.rightsOpen Access
dc.sourceRathakrishnan, A., Hemmink, J.D., Petrovan, V., Reis, A.L. and Dixon, L.K. 2025. Gene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX. Emerging Microbes and Infections 14(1): 2505645.
dc.subjectafrican swine fever
dc.subjectswine
dc.subjectvaccines
dc.titleGene-modified genotype II live attenuated African swine fever virus induces cross-protection against genotype I but not against genotype IX
dc.typeJournal Article

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