Determinants of vitamin D status in Kenyan calves

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dc.creatorCallaby, R.
dc.creatorHurst, E.
dc.creatorHandel, Ian G.
dc.creatorToye, Philip G.
dc.creatorBronsvoort, B.M. de C.
dc.creatorMellanby, R.J.
dc.date2020-11-25
dc.date2020-11-30T12:40:56Z
dc.date2020-11-30T12:40:56Z
dc.date.accessioned2026-06-27T16:39:50Z
dc.descriptionVitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period.
dc.identifierhttps://hdl.handle.net/10568/110355
dc.identifier.urihttp://hdl.handle.net/123456789/129697
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceCallaby, R., Hurst, E., Handel, I., Toye, P., Bronsvoort, B.M. de C. and Mellanby, R.J. 2020. Determinants of vitamin D status in Kenyan calves. Scientific Reports 10:20590
dc.subjectanimal diseases
dc.subjectanimal health
dc.subjectinfectious diseases
dc.subjectcalves
dc.subjectlivestock
dc.titleDeterminants of vitamin D status in Kenyan calves
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)