Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.

Vista sencilla de ítem
dc.contributorMaría Olimpia Paz Alvarenga, UFPA; Leonardo Oliveira Bittencourt, UFPA; Paulo Fernando Santos Mendes, UFPA; Julia Turra Ribeiro, UFRGS; OSMAR ALVES LAMEIRA, CPATU; Marta Chagas Monteiro, UFPA; Carlos Augusto Galvão Barboza, UFRGS; Manoela Domingues Martins, UFRGS; Rafael Rodrigues Lima, UFPA.
dc.creatorALVARENGA, M. O. P.
dc.creatorBITTENCOURT, L. O.
dc.creatorMENDES, P. F. S.
dc.creatorRIBEIRA, J. T.
dc.creatorLAMEIRA, O. A.
dc.creatorMONTEIRO, M. C.
dc.creatorBARBOZA, C. A. G.
dc.creatorMARTINS, M. D.
dc.creatorLIMA, R. R.
dc.date2020-05-19T04:39:20Z
dc.date2020-05-19T04:39:20Z
dc.date2020-05-18
dc.date2020
dc.date.accessioned2026-06-30T23:49:16Z
dc.descriptionIn traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model.
dc.identifierInternational Journal of Molecular Science, v. 21, n. 10, article 3568, 2020.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1122369
dc.identifierhttps://doi.org/10.3390/ijms21103568
dc.identifier.urihttp://hdl.handle.net/123456789/391089
dc.languageeng
dc.rightsopenAccess
dc.subjectCopaíba
dc.subjectAntiinflamatório
dc.subjectTerapia
dc.subjectOleorresina
dc.subjectCicatrização
dc.titleSafety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.
dc.typeArtigo de periódico

Archivos

Colecciones

Embrapa Amazonía Oriental (CPATU)