Calcium supplementation for the prevention of hypertensive disorders of pregnancy: Current evidence and programmatic considerations

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dc.creatorGomes, Filomena
dc.creatorAshorn, Per
dc.creatorAskari, Sufia
dc.creatorBelizán, José M.
dc.creatorBoy, Erick
dc.date2022-04
dc.date2024-04-12T13:37:32Z
dc.date2024-04-12T13:37:32Z
dc.date.accessioned2026-06-27T15:42:38Z
dc.descriptionMost low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5–2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.
dc.identifierhttps://hdl.handle.net/10568/141248
dc.identifier.urihttp://hdl.handle.net/123456789/112444
dc.languageen
dc.publisherNew York Academy of Sciences
dc.rightsOpen Access
dc.sourceGomes, Filomena; Ashorn, Per; Askari, Sufia; Belizan, Jose M.; Boy, Erick; et al. 2022. Calcium supplementation for the prevention of hypertensive disorders of pregnancy: Current evidence and programmatic considerations. Annals of the New York Academy of Sciences 1510(1): 52-67. https://doi.org/10.1111/nyas.14733
dc.subjectcalcium
dc.subjectpregnancy
dc.subjectmineral deficiencies
dc.subjectsupplements
dc.subjectpregnancy complications
dc.subjecthypertension
dc.titleCalcium supplementation for the prevention of hypertensive disorders of pregnancy: Current evidence and programmatic considerations
dc.typeJournal Article

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Instituto Internacional de Investigación sobre Políticas Alimentarias (IFPRI)