In vivo role of capsular polysaccharide in Mycoplasma mycoides

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dc.creatorJores, Joerg
dc.creatorSchieck, Elise G.
dc.creatorLiljander, Anne M.
dc.creatorSacchini, Flavio
dc.creatorPosthaus, H.
dc.creatorLartigue, C.
dc.creatorBlanchard, Alain
dc.creatorLabroussaa, F.
dc.creatorVashee, S.
dc.date2019-04-19
dc.date2019-01-02T12:19:18Z
dc.date2019-01-02T12:19:18Z
dc.date.accessioned2026-06-27T16:34:27Z
dc.descriptionCapsular polysaccharides have been confirmed to be an important virulence trait in many gram-positive and gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In the current study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. capri or an engineered mutant lacking the capsular polysaccharide, galactofuranose. Goats infected with the mutant strain showed only transient fever. In contrast, 5 of 8 goats infected with the parental strain reached end-point criteria after infection. These findings confirm that galactofuranose is a virulence factor in M. mycoides.
dc.identifierhttps://hdl.handle.net/10568/98924
dc.identifier.urihttp://hdl.handle.net/123456789/126944
dc.languageen
dc.publisherOxford University Press
dc.rightsOpen Access
dc.sourceJores, J., Schieck, E., Liljander, A., Sacchini, F., Posthaus, H., Lartigue, C., Blanchard, A., Labroussaa, F. and Vashee, S. 2019. In vivo role of capsular polysaccharide in Mycoplasma mycoides. Journal of Infectious Diseases 219(10):1559–1563.
dc.subjectanimal diseases
dc.subjecthealth
dc.subjectgoats
dc.subjectsmall ruminants
dc.subjectvaccines
dc.subjectzoonoses
dc.subjectinfectious diseases
dc.titleIn vivo role of capsular polysaccharide in Mycoplasma mycoides
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)