Molecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda

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dc.creatorAlinaitwe, Lordrick
dc.creatorWainaina, Martin
dc.creatorDürr, S.
dc.creatorKankya, C.
dc.creatorKivali, Velma
dc.creatorBugeza, James
dc.creatorAturinda, C.J.
dc.creatorLubega, A.
dc.creatorMayer-Scholl, A.
dc.creatorHoona, J.J.
dc.creatorBahn, P.
dc.creatorHammerl, J.A.
dc.creatorRoesel, Kristina
dc.creatorCook, Elizabeth A.J.
dc.creatorRichter, M.H.
dc.date2025
dc.date2025-04-02T05:23:03Z
dc.date2025-04-02T05:23:03Z
dc.date.accessioned2026-06-27T16:45:05Z
dc.description<i>Leptospira</i> are bacteria that cause leptospirosis in both humans and animals. Human <i>Leptospira</i> infections in Uganda are suspected to arise from animal–human interactions. From a nationwide survey to determine Leptospira prevalence and circulating sequence types in Uganda, we tested 2030 livestock kidney samples, and 117 small mammals (rodents and shrews) using real-time PCR targeting the lipL32 gene. Pathogenic <i>Leptospira</i> species were detected in 45 livestock samples but not in the small mammals. The prevalence was 6.12% in sheep, 4.25% in cattle, 2.08% in goats, and 0.46% in pigs. Sequence typing revealed that <i>Leptospira borgpetersenii</i>, <i>Leptospira kirschneri</i>, and <i>Leptospira interrogans</i> are widespread across Uganda, with 13 novel sequence types identified. These findings enhance the East African MLST database and support the hypothesis that domesticated animals may be a source of human leptospirosis in Uganda, highlighting the need for increased awareness among those in close contact with livestock.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/173963
dc.identifier.urihttp://hdl.handle.net/123456789/132176
dc.languageen
dc.publisherCambridge University Press
dc.rightsOpen Access
dc.sourceAlinaitwe, L., Wainaina, M., Dürr, S., Kankya, C., Kivali, V., Bugeza, J., Aturinda, C.J., Lubega, A., Mayer-Scholl, A., Hoona, J.J., Bahn, P., Hammerl, J.A., Roesel, K., Cook, E.A.J. and Richter, M.H. 2025. Molecular detection and typing of pathogenic <i>Leptospira</i> species from livestock and small mammals in Uganda. Epidemiology and Infection 153: e50.
dc.subjectcattle
dc.subjectepidemiology
dc.subjectgoats
dc.subjectleptospira
dc.subjectlivestock
dc.subjectsmall ruminants
dc.subjectswine
dc.subjectzoonoses
dc.titleMolecular detection and typing of pathogenic Leptospira species from livestock and small mammals in Uganda
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)