Highthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance

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dc.creatorBart, R.
dc.creatorCohn, M.
dc.creatorKassen, A.
dc.creatorMcCallum, E.
dc.creatorShybut, M.
dc.creatorPetriello, A.
dc.creatorKrasileva, K.
dc.creatorDahlbeck, D.
dc.creatorMedina, C.
dc.creatorAlicai, Titus
dc.creatorKumar, P. Lava
dc.creatorMoreira, L.
dc.creatorNeto, J.
dc.creatorVerdier, Valerie M.
dc.creatorSantana, M.
dc.creatorKositcharoenkul, N.
dc.creatorVanderschuren, H.
dc.creatorGruissem, W.
dc.creatorBernal, A.
dc.creatorStaskawicz, B.
dc.date2012-07-10
dc.date2017-02-13T13:41:47Z
dc.date2017-02-13T13:41:47Z
dc.date.accessioned2026-06-27T15:57:02Z
dc.descriptionCassava bacterial blight (CBB), incited by Xanthomonas axonopodis pv. manihotis (Xam), is the most important bacterial disease of cassava, a staple food source for millions of people in developing countries. Here we present a widely applicable strategy for elucidating the virulence components of a pathogen population. We report Illumina-based draft genomes for 65 Xam strains and deduce the phylogenetic relatedness of Xam across the areas where cassava is grown. Using an extensive database of effector proteins from animal and plant pathogens, we identify the effector repertoire for each sequenced strain and use a comparative sequence analysis to deduce the least polymorphic of the conserved effectors. These highly conserved effectors have been maintained over 11 countries, three continents, and 70 y of evolution and as such represent ideal targets for developing resistance strategies.
dc.identifierhttps://hdl.handle.net/10568/79848
dc.identifier.urihttp://hdl.handle.net/123456789/118312
dc.languageen
dc.publisherNational Academy of Sciences
dc.rightsOpen Access
dc.sourceBart, R., Cohn, M., Kassen, A., McCallum, E., Shybut, M., Petriello, A., … Staskawicz, B. (2012). Highthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable. Resistance. In: Proceedings of the National Academy of Sciences of the United States of America, 109(28), E1972-E1979.
dc.subjectinnate immunity
dc.subjecttype three effectors
dc.subjectnext-generation sequencing
dc.subjectcassava
dc.subjectplant diseases
dc.subjectxanthomonas axonopodis
dc.titleHighthroughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance
dc.typeJournal Article

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Instituto Internacional de Agricultura Tropical (IITA)