Identification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution

Vista sencilla de ítem
dc.creatorMacHugh, Niall D.
dc.creatorMburu, J.K.
dc.creatorCarol, M.J.
dc.creatorWyatt, C.R.
dc.creatorOrden, J.A.
dc.creatorDavis, W.C.
dc.date1997
dc.date2013-05-06T07:01:13Z
dc.date2013-05-06T07:01:13Z
dc.date.accessioned2026-06-27T17:10:12Z
dc.descriptionWe describe the characterization of two subsets of bovine gamma delta T cells having distinct cell surface phenotype and tissue distribution. One population expresses the previously described 215000 MW WC1 antigen and is negative for the cell-surface differentiation antigens CD2. CD4, and CD8. The second population expresses CD2 and CD8 but not WC1 and appears to have a T-cell receptor (TCR) rearrangement distinct from that of the WC1+ population. The WC1- population is found in large numbers in spleen and intestine. In addition. This subset is not recognized by a number of monoclonal antibodies (mAbs) specific for TCR families that are well represented in the WC1+_ population. The results indicate that the gamma delta T-cell population in cattle is considerably larger than previously described and that this population can be subdivided into two distinct subsets based on cell-surface phenotype and tissue distribution.
dc.identifierhttps://hdl.handle.net/10568/28704
dc.identifier.urihttp://hdl.handle.net/123456789/144272
dc.languageen
dc.rightsLimited Access
dc.sourceImmunology;92(2): 340-345
dc.subjectbovinae
dc.subjectcells
dc.subjectphenotypes
dc.subjectgenetic transformation
dc.titleIdentification of two distinct subsets of gamma/delta T cells with unique cell surface phenotype and tissue distribution
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)