Microwave-assisted catalytic transfer hydrogenation of chalcones: a green, fast, and efficient one-step reduction using ammonium formate and Pd/C.

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dc.contributorWENDER ALVES SILVA, UNIVERSITY OF BRASILIA (IQ-UNB); SAYURI CRISTINA SANTOS TAKADA DA SILVA, CENARGEN; FELIPE MARQUES NOGUEIRA, UNIVERSITY OF BRASILIA (IQ-UNB); LUIZ ARTHUR RAMOS ALMEIDA, UNIVERSITY OF BRASILIA (IQ-UNB).
dc.creatorSILVA, W. A.
dc.creatorSILVA, S. C. S. T. da
dc.creatorNOGUEIRA, F. M.
dc.creatorALMEIDA, L. A. R.
dc.date2025-09-09T12:49:27Z
dc.date2025-09-09T12:49:27Z
dc.date2025-09-09
dc.date2025
dc.date.accessioned2026-07-07T11:56:38Z
dc.descriptionCatalytic transfer hydrogenation (CTH) and microwave-assisted organic synthesis (MAOS) have each advanced the sustainability of reduction chemistry; however, their combined application to conjugated enones remains largely unexplored. To the best of our knowledge, no unified protocol has been reported for the rapid, one-pot conversion of chalcones into saturated alcohols under microwave irradiation. Herein, we report a concise and green method that integrates MAOS with Pd/C-catalyzed CTH, employing inexpensive ammonium formate in ethanol. In contrast to state-of-the-art hydrogenations that require pressurized H2 or costly metal complexes, our strategy (i) achieves complete conversion within 20 min at 60 °C, (ii) tolerates both electron-rich and electron-poor substrates, (iii) reduces nitro-substituted chalcones in a single step, and (iv) consumes < 0.005 kWh per reaction—an approximately 250-fold energy saving relative to conventional procedures. These results position microwave-driven CTH as a scalable alternative for synthesizing pharmacologically relevant saturated alcohol scaffolds from readily available chalcones.
dc.descriptionNa publicação: Sayuri Cristina Santos Takada.
dc.identifierOrganics, v. 6, n. 3, 40, 2025.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1178641
dc.identifier.urihttp://hdl.handle.net/123456789/518422
dc.languageeng
dc.rightsopenAccess
dc.subjectMicrowave-assisted synthesis
dc.subjectCatalytic transfer hydrogenation
dc.subjectEnergy-efficient synthesis
dc.subjectChalcones
dc.subjectGreen chemistry
dc.titleMicrowave-assisted catalytic transfer hydrogenation of chalcones: a green, fast, and efficient one-step reduction using ammonium formate and Pd/C.
dc.typeArtigo de periódico

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