Cellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.

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dc.contributorCAIO CÉSAR DE SOUZA ALVES, UFJF
dc.contributorANA LUISA SOUSA AZEVEDO, CNPGL
dc.contributorMICHELE F. RODRIGUES, UFJF
dc.contributorRACHEL P. MACHADO, UFJF
dc.contributorSUPREMA
dc.contributorMARIA A. SOUZA, UFJF
dc.contributorMARCO ANTONIO MACHADO, CNPGL
dc.contributorHENRIQUE C. TEIXEIRA, UFJF
dc.contributorANA P. FERREIRA, UFJF.
dc.creatorALVES, C. C. de S.
dc.creatorAZEVEDO, A. L. S.
dc.creatorRODRIGUES, M. F.
dc.creatorMACHADO, R. P.
dc.creatorSOUZA, M. A.
dc.creatorMACHADO, M. A.
dc.creatorTEIXEIRA, H. C.
dc.creatorFERREIRA, A. P.
dc.date2024-02-16T18:32:27Z
dc.date2024-02-16T18:32:27Z
dc.date2010-04-20
dc.date2009
dc.date.accessioned2026-07-07T03:51:22Z
dc.descriptionParacoccidioidomycosis is a chronic infection that primarily affects the lungs. Here we investigated cellular and humoral immune responses after intrathoracic Paracoccidioidesbrasiliensis infection in BALB/c mice. P. brasiliensis-colony-forming units (CFUs), fungal DNA and granulomas in lungs increased progressively, peaking at day 90 postinfection (p.i.). IFN-γ production was highest on day 15 p.i., declining thereafter. The kinetics of the NO production was similar to that described for IFN-γ. In contrast, IL-10 increased from day 45 p.i. reaching a peak at day 90. Levels of serum IgG1 were higher than IgG2a between days 30 and 90 p.i. 30% of mice died by day 90 p.i. These data indicate that infection with P. brasiliensis by the intrathoracic route shows high IFN-γ and NO production at day 15 p.i., unable to control multiplication of fungi, which appears to be associated with a progressive increase in IL-10 and in the number and complexity of granulomas.
dc.identifierComparative Immunology, Microbiology and Infectious Discases, v. 32, n. 6, p. 513-525, 2009.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/697051
dc.identifierhttps://doi.org/10.1016/j.cimid.2008.07.006
dc.identifier.urihttp://hdl.handle.net/123456789/444982
dc.languageeng
dc.rightsopenAccess
dc.subjectIFN-y
dc.subjectIL-10
dc.subjectAntibody response
dc.subjectIntrathoracic route
dc.subjectParacoccidioides brasiliensis
dc.titleCellular and humoral immune responses during intrathoracic paracoccidioidomycosis in BALB/c mice.
dc.typeArtigo de periódico

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