FAO/WHO Expert Consultation on the Safety Assessment of Foods Derived from Recombinant-DNA Animals. Report
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A joint FAO/WHO Expert Consultation on the Safety Assessment of Foods Derived from Recombinant-DNA Animals was held at the Headquarters of the World Health Organization (WHO) in Geneva from 26 February to 2 March 2007. The objective was to provide scientific advice to FAO/WHO and their Member States on two sets of questions regarding: i) marker and reporter genes; and ii) non-heritable applications. The Codex ad hoc Intergovernmental Task Force on Foods Derived from Biotechnology had specificall y requested advice on these questions. This Consultation built upon the conclusions and recommendations from the Joint FAO/WHO Expert Consultation on the Safety Assessment of Foods Derived from Genetically Modified Animals, including Fish (FAO/WHO 2004). A variety of reporter and selectable marker genes are used extensively in plants and laboratory animals and are now being used in food animals. Few non-antibiotic resistance marker and reporter genes are currently used for producing recombinant- DNA animals intended for food and no studies are available on their food safety. It would be desirable to develop new selectable marker genes that do not confer antibiotic resistance.