Updated joint FAO/WHO/WOAH public health assessment of recent influenza A(H5) virus events in animals and people
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FAO ; WHO ; World Organisation for Animal Health (WOAH) ;
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During 2020, high pathogenicity avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses arose from previously circulating influenza A(H5Nx) viruses and spread predominantly via migratory birds to many parts of Africa, Asia and Europe. This epizootic event has led to unprecedented numbers of deaths in wild birds and caused outbreaks in poultry. In late 2021, these viruses crossed the Atlantic Ocean to North America and subsequently reached South America in October 2022, and the Antarctica Region in October 2023. Over the past few years, there have been increased detections of A(H5N1) viruses in non-avian species globally including wild and domestic (companion and farmed) terrestrial and marine mammals, with recent cases in livestock in the United States of America. The majority of A(H5N1) viruses characterized genetically since 2020 belong to the haemagglutinin (HA) H5 clade 2.3.4.4b, with some regional exceptions.This risk assessment from FAO, WHO, and WOAH updates the assessment of the risk of zoonotic transmission (for example, animal to human) considering additional information made available since the previous assessment of 20 December 2024. This update is limited to the inclusion of additional information being made available globally. Due to the potential risk to human health and the far-reaching implications of the disease on the health of wild birds, poultry, livestock and other animal populations, the use of a One Health approach is essential to tackle avian influenza effectively, to monitor and characterize virus circulation, to prevent within species and to new species transmission, to reduce spread among animals, and to prevent human infections from exposure to animals.