The emerging role of microRNAs in bone diseases and their therapeutic potential

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dc.creatorBravo Vázquez, Luis Alberto
dc.creatorMoreno Becerril, Mariana Yunuen
dc.creatorMora Hernández, Erick Octavio
dc.creatorLeón Carmona, Gabriela García de
dc.creatorAguirre Padilla, María Emilia
dc.creatorChakraborty, Samik
dc.creatorBandyopadhyay, Anindya
dc.creatorPaul, Sujay
dc.date2021-12-30
dc.date2024-12-19T12:53:30Z
dc.date2024-12-19T12:53:30Z
dc.date.accessioned2026-06-27T04:14:18Z
dc.descriptionMicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments.
dc.identifierhttps://hdl.handle.net/10568/164142
dc.identifier.urihttp://hdl.handle.net/123456789/26135
dc.languageen
dc.publisherMDPI
dc.rightsOpen Access
dc.sourceBravo Vázquez, L.A., Moreno Becerril, M.Y., Mora Hernández, E.O., León Carmona, G.G. de, Aguirre Padilla, M.E., Chakraborty, S., Bandyopadhyay, A. and Paul, S. 2021. The emerging role of microRNAs in bone diseases and their therapeutic potential. Molecules, Volume 27 no. 1 p. 211
dc.subjectchemistry (miscellaneous)
dc.subjectanalytical chemistry
dc.subjectorganic chemistry
dc.subjectphysical and theoretical chemistry
dc.subjectmolecular medicine
dc.subjectdrug discovery
dc.subjectpharmaceutical science
dc.titleThe emerging role of microRNAs in bone diseases and their therapeutic potential
dc.typeJournal Article

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Instituto Internacional de Investigación del Arroz (IRRI)