In vitro ovicidal and larvicidal activity of the leaf, bark and root extracts of Peltophorum africanum Sond. (Fabaceae) on Haemonchus contortus

Bizimenyera, E.S.; Githiori, J.B.; Swan, G.E.; Eloff, J.N.

In vitro ovicidal and larvicidal activity of the leaf, bark and root extracts of Peltophorum africanum Sond. (Fabaceae) on Haemonchus contortus

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The In vitro efficacy of the extracts of Peltophorum africanum Sond. (Fabaceae), was determined against Haemonchus contortus. Acetone extracts of the leaf, bark and root, at concentrations of 0.008 to 25 mg mL 1 were incubated at 23oC with the eggs and larval stage (L1) of the parasite for two and five days, respectively. Thiabendazole and water were positive and negative controls, respectively. Increasing the concentration of extracts caused a significant (p<0.05) increase in inhibition of egg hatching, and larval development. At concentrations of 0.2 and 1.0 mg mL 1 the extracts inhibited egg hatching and development of L1 to the infective stage (L3). No eggs and larvae (L1) of H. contortus were detected at concentrations of 5 and 25 mg mL 1. The in vitro model may provide support of the traditional use of P. africanum extracts against helminthosis. Suitable methods of plant extraction, adaptable to rural use may help rural communities control helminthosis.