GC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.

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dc.contributorJHONYSON ARRUDA CARVALHO GUEDES, UNIVERSIDADE FEDERAL DO CEARÁ
dc.contributorELENILSON DE GODOY ALVES FILHO
dc.contributorMARIA FRANCILENE SOUZA SILVA, UNIVERSIDADE FEDERAL DO CEARÁ
dc.contributorTIGRESSA HELENA SOARES RODRIGUES, UNIVERSIDADE ESTADUAL DO VALE DO ACARAÚ
dc.contributorCHRISTIANE MENDES CASSIMIRO RAMIRES, EMPRESA ESTADUAL DE PESQUISA AGROPECUÁRIA DA PARAÍBA
dc.contributorMARIA AUXILIADORA COELHO DE LIMA, CPATSA
dc.contributorGISELE SILVESTRE DA SILVA
dc.contributorCLAUDIA DO Ó PESSOA, UNIVERSIDADE FEDERAL DO CEARÁ
dc.contributorKIRLEY MARQUES CANUTO, CNPAT
dc.contributorEDY SOUSA DE BRITO, CNPAT
dc.contributorRICARDO ELESBAO ALVES, CNAT
dc.contributorRONALDO FERREIRA DO NASCIMENTO, UNIVERSIDADE FEDERAL DO CEARÁ
dc.contributorGUILHERME JULIAO ZOCOLO, CNPAT.
dc.creatorGUEDES, J. A. C.
dc.creatorALVES FILHO, E. DE G.
dc.creatorSILVA, M. F. S.
dc.creatorRODRIGUES, T. H. S.
dc.creatorRAMIRES, C. M. C.
dc.creatorLIMA, M. A. C. de
dc.creatorSILVA, G. S. DA
dc.creatorPESSOA, C. DO Ó
dc.creatorCANUTO, K. M.
dc.creatorBRITO, E. S. de
dc.creatorALVES, R. E.
dc.creatorNASCIMENTO, R. F. DO
dc.creatorZOCOLO, G. J.
dc.date2020-02-13T18:16:16Z
dc.date2020-02-13T18:16:16Z
dc.date2020-02-13
dc.date2020
dc.date2020-04-17T11:11:11Z
dc.date.accessioned2026-07-07T05:55:50Z
dc.descriptionAgroindustrial residues, such as leaves of fruit plants, can be sources of bioactive molecules, thus adding value to co-products that are rarely explored in agroindustry. In this context, this study aimed to look into the phytochemical profiles in detail and to explore the antitumor potential of S. tuberosa and S. mombin leaves. We observed that, S. tuberosa leaf extract was cytotoxic in both tumor and healthy cells. S. mombin extracts selectively inhibited cell proliferation in the tumor cell line for prostate cancer (PC3) and did not significantly affect healthy cells. The metabolic profiles of the extracts were evaluated by gas chromatography coupled with mass spectrometry and twenty-three metabolites were identified. The correlation of metabolic profiles with cytotoxic tests indicated possible chemical markers that may be responsible for the inhibition of cell proliferation. This study revealed that the unexplored co-products in agroindustry may have great therapeutic potential, and therefore should be screened for biologically active compounds
dc.formatp. 331-340
dc.identifierJournal of the Brazilian Chemical Society, v. 31, n. 2, p. 331-340, 2020.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1120219
dc.identifier10.21577/0103-5053.20190185
dc.identifier.urihttp://hdl.handle.net/123456789/502801
dc.languageeng
dc.rightsopenAccess
dc.subjectMetabolômica
dc.subjectResiduo agroindustrial
dc.subjectAgroindustria
dc.subjectCo-produto
dc.subjectSpondias Mombin
dc.subjectUmbu
dc.subjectCromatografia
dc.subjectYellow mombins
dc.subjectChromatography
dc.subjectMetabolomics
dc.subjectSpondias
dc.titleGC-MS-based metabolomic profiles combined with chemometric tools and cytotoxic activities of non-polar leaf extracts of Spondias mombin L. and Spondias tuberosa Arr. Cam.
dc.typeArtigo de periódico

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