MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G

Vista sencilla de ítem
dc.creatorArfi, Yonathan
dc.creatorMinder, Laetitia
dc.creatorPrimo, Carmelo di
dc.creatorLe Roy, Aline
dc.creatorEbel, Christine
dc.creatorCoquet, Laurent
dc.creatorClaverol, Stephane
dc.creatorVashee, Sanjay
dc.creatorJores, Joerg
dc.creatorBlanchard, Alain
dc.creatorSirand-Pugnet, Pascal
dc.date2016-05-10
dc.date2023-03-10T14:36:35Z
dc.date2023-03-10T14:36:35Z
dc.date.accessioned2026-06-27T17:06:14Z
dc.descriptionMycoplasmas are minimal pathogenic bacteria able to infect humans and a wide range of economically important animals; as such, they are major causes of concern in the medical and veterinary fields. These pathogens often lead to chronic infections, and their mechanisms of immunity evasion are poorly known. Here we describe a two-protein system from the ruminant pathogenMycoplasma mycoidessubspeciescaprithat is involved in the capture and cleavage of antibodies. MIB is able to capture the antibodies and to subsequently recruit MIP, a protease that is able to cleave the antibody heavy chain. The MIB–MIP system appears to be widespread among pathogenic mycoplasmas and is potentially a key player for the virulence and immunity evasion mechanisms of these bacteria.
dc.identifierhttps://hdl.handle.net/10568/129486
dc.identifier.urihttp://hdl.handle.net/123456789/142285
dc.languageen
dc.publisherNational Academy of Sciences
dc.rightsOpen Access
dc.sourceArfi, Yonathan; Minder, Laetitia; Primo, Carmelo di; Le Roy, Aline; Ebel, Christine; Coquet, Laurent; Claverol, Stephane; Vashee, Sanjay; Jores, Joerg; Blanchard, Alain; Sirand-Pugnet, Pascal. 2016. MIB-MIP is a mycoplasma system that captures and cleaves immunoglobulin G. Proceedings of the National Academy of Sciences 113: 5406-5411
dc.subjectmycoplasma
dc.subjectsystem
dc.titleMIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)