Mechanisms of pyrethroid resistance in Haematobia irritans (Muscidae) from Mato Grosso do Sul state, Brazil.

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dc.creatorBARROS, A. T. M. de
dc.creatorSCHUMAKER, T. T. S.
dc.creatorKOLLER, W. W.
dc.creatorKLAFKE, G. M.
dc.creatorALBUQUERQUE, T. A. de
dc.creatorGONZALEZ, R.
dc.date2013-11-08T11:11:11Z
dc.date2013-11-08T11:11:11Z
dc.date2013-11-08
dc.date2013
dc.date2013-11-08T11:11:11Z
dc.date.accessioned2026-07-07T03:38:12Z
dc.descriptionHorn fly resistance to pyrethroid insecticides occurs throughout Brazil, but knowledge about the involved mechanisms is still in an incipient stage. This survey was aimed to identify the mechanisms of horn fly resistance to cypermethrin in Mato Grosso do Sul state, Brazil. Impregnated filter paper bioassays using cypermethrin, synergized or not with piperonyl butoxide (PBO) and triphenyl phosphate (TPP), were conducted from March 2004 to June 2005 in horn fly populations (n = 33) from all over the state. All populations were highly resistant to cypermethrin, with resistance factors (RF) ranging from 89.4 to 1,020.6. Polymerase chain reaction (PCR) assays to detect the knockdown resistance (kdr) mutation also were performed in 16 samples. The kdr mutation was found in 75% of the tested populations, mostly with relatively low frequencies (<20%), and was absent in some highly resistant populations. Addition of TPP did not significantly reduce the LC50 in any population. However, PBO reduced LC50s above 40-fold in all tested populations, resulting in RFs ? 10 in most cases. Horn fly resistance to cypermethrin is widespread in the state, being primarily caused by an enhanced activity of P450 mono-oxygenases and secondarily by reduced target site sensitivity.
dc.identifierRevista Brasileira de Parasitologia Veterinária v. 22, n. 1, p. 136-142, 2013.
dc.identifier0103-846X
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/970876
dc.identifier.urihttp://hdl.handle.net/123456789/439124
dc.languagepor
dc.rightsopenAccess
dc.subjectHorn fly
dc.subjectKdr
dc.subjectMetabolic resistance
dc.subjectMosca-dos-chifres
dc.subjectResistência a inseticidas
dc.subjectResistência metabólica
dc.subjectinsecticide resistance
dc.titleMechanisms of pyrethroid resistance in Haematobia irritans (Muscidae) from Mato Grosso do Sul state, Brazil.
dc.typeArtigo de periódico

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