Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep

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dc.creatorYin-Hong Cao
dc.creatorSong-Song Xu
dc.creatorMin Shen
dc.creatorZe-Hui Chen
dc.creatorLei Gao
dc.creatorFeng-Hua Lv
dc.creatorXing-Long Xie
dc.creatorXin-Hua Wang
dc.creatorHua Yang
dc.creatorChang-Bin Liu
dc.creatorPing Zhou
dc.creatorPeng-Cheng Wan
dc.creatorYun-Sheng Zhang
dc.creatorJing-Quan Yang
dc.creatorWen-Hui Pi
dc.creatorEer Hehua
dc.creatorBerry, D.P.
dc.creatorBarbato, M.
dc.creatorEsmailizadeh, A.
dc.creatorNosrati, M.
dc.creatorSalehian-Dehkordi, H.
dc.creatorDehghani-Qanatqestani, M.
dc.creatorDotsev, A.V.
dc.creatorDeniskova, T.E.
dc.creatorZinovieva, N.A.
dc.creatorBrem, G.
dc.creatorŠtěpánek, O.
dc.creatorCiani, E.
dc.creatorWeimann, C.
dc.creatorErhardt, G.
dc.creatorMwacharo, Joram M.
dc.creatorAhbara, A.
dc.creatorHan Jianlin
dc.creatorHanotte, Olivier H.
dc.creatorMiller, J.M.
dc.creatorSim, Z.
dc.creatorZijian Sim
dc.creatorColtman, D.
dc.creatorKantanen, J.
dc.creatorBruford, M.W.
dc.creatorLenstra, J.A.
dc.creatorKijas, J.
dc.creatorMeng-Hua Li
dc.date2021-03-09
dc.date2020-11-10T13:56:13Z
dc.date2020-11-10T13:56:13Z
dc.date.accessioned2026-06-27T17:20:23Z
dc.descriptionHow animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600K and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667–248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication.
dc.identifierhttps://hdl.handle.net/10568/110111
dc.identifier.urihttp://hdl.handle.net/123456789/149335
dc.languageen
dc.publisherOxford University Press
dc.rightsOpen Access
dc.sourceYin-Hong Cao, Song-Song Xu, Min Shen, Ze-Hui Chen, Lei Gao, Feng-Hua Lv, Xing-Long Xie, Xin-Hua Wang, Hua Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Jing-Quan Yang, Wen-Hui Pi, EEr, H., Berry, D.P., Barbato, M., Esmailizadeh, A., Nosrati, M., Salehian-Dehkordi, H., Dehghani-Qanatqestani, M., Dotsev, A.V., Deniskova, T.E., Zinovieva, N.A., Brem, G., Štěpánek, O., Ciani, E., Weimann, C., Erhardt, G., Mwacharo, J.M., Ahbara, A., Han Jianlin, Hanotte, O.H., Miller, J.M., Zijian Sim, Coltman, D., Kantanen, J., Bruford, M.W., Lenstra, J.A., Kijas, J., Meng-Hua Li. 2020. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep. Molecular Biology and Evolution
dc.subjectsheep
dc.subjectclimate change
dc.subjectanimal breeding
dc.subjectlivestock
dc.subjectindigenous breeds
dc.titleHistorical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep
dc.typeJournal Article

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