Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin‑controlled release.

BERNARDI, B.; MALAFATTI, J. O. D.; MOREIRA, A. J.; NASCIMENTO, A. C. A.; LIMA, J. B.; VERMEERSCH, L. A. F.; PARIS, E. C.

Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin‑controlled release.

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Descripción

Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric bers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m2 g−1 ), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h). Zeolites were incorporated into polymeric nanobers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an ecient synthesis method. The bers produced showed good mechanical resistance and the ncorporation of CLX was proven by assays to inhibit the growth of Staphylococcus aureus bacteria. The controlled release of CLX in dierent pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 ± 0.02 mg L−1 . These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods.