Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia

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dc.creatorTotte, Philippe
dc.creatorYaya, Aboubakar
dc.creatorSery, Amadou
dc.creatorWesonga, Hezron
dc.creatorWade, Abel
dc.creatorNaessens, Jan
dc.creatorNiang, Mamadou
dc.creatorThiaucourt, François
dc.date2013-02-28
dc.date2023-03-10T14:34:44Z
dc.date2023-03-10T14:34:44Z
dc.date.accessioned2026-06-27T17:18:03Z
dc.descriptionA better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines.
dc.identifierhttps://hdl.handle.net/10568/129413
dc.identifier.urihttp://hdl.handle.net/123456789/148177
dc.languageen
dc.publisherPublic Library of Science
dc.rightsOpen Access
dc.sourceTotte, Philippe; Yaya, Aboubakar; Sery, Amadou; Wesonga, Hezron; Wade, Abel; Naessens, Jan; Niang, Mamadou; Thiaucourt, François. 2013. Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia. PLoS ONE 8: e57509
dc.subjectvaccines
dc.subjectcontagious bovine pleuropneumonia
dc.subjectbovine
dc.subjectpleuropneumonia
dc.titleCharacterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)