The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation

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dc.creatorZan, Yanjun
dc.creatorChen, Shuai
dc.creatorRen, Min
dc.creatorLiu, Guoxiang
dc.creatorLiu, Yutong
dc.creatorHan, Yu
dc.creatorDong, Yang
dc.creatorZhang, Yao
dc.creatorSi, Huan
dc.creatorLiu, Zhengwen
dc.creatorLiu, Dan
dc.creatorZhang, Xingwei
dc.creatorTong, Ying
dc.creatorLi, Yuan
dc.creatorJiang, Caihong
dc.creatorWen, Liuying
dc.creatorXiao, Zhiliang
dc.creatorSun, Yangyang
dc.creatorGeng, Ruimei
dc.creatorJi, Yan
dc.creatorFeng, Quanfu
dc.creatorWang, Yuanying
dc.creatorYe, Guoyou
dc.creatorFang, Lingzhao
dc.creatorChen, Yong
dc.creatorCheng, Lirui
dc.creatorYang, Aiguo
dc.date2025-04
dc.date2025-05-07T08:48:24Z
dc.date2025-05-07T08:48:24Z
dc.date.accessioned2026-06-27T04:08:11Z
dc.descriptionNicotiana tabacum is an allotetraploid hybrid of Nicotiana sylvestris and Nicotiana tomentosiformis and a model organism in genetics. However, features of subgenome evolution, expression coordination, genetic diversity and complex traits regulation of N. tabacum remain unresolved. Here we present chromosome-scale assemblies for all three species, and genotype and phenotypic data for 5,196 N. tabacum germplasms. Chromosome rearrangements and epigenetic modifications are associated with genome evolution and expression coordination following polyploidization. Two subgenomes and genes biased toward one subgenome contributed unevenly to complex trait variation. Using 178 marker–trait associations, a reference genotype-to-phenotype map was built for 39 morphological, developmental and disease resistance traits, and a novel gene regulating leaf width was validated. Signatures of positive and polygenic selection during the process of selective breeding were detected. Our study provides insights into genome evolution, complex traits regulation in allotetraploid N. tabacum and the use of GeneBank-scale resources for advancing genetic and genomic research.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/174451
dc.identifier.urihttp://hdl.handle.net/123456789/22708
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceZan, Yanjun, Shuai Chen, Min Ren, Guoxiang Liu, Yutong Liu, Yu Han, Yang Dong et al. "The genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation." Nature Genetics (2025): 1-11.
dc.subjectnicotiana tabacum
dc.subjectpolyploidy
dc.subjectchromosomes
dc.subjectepigenetics
dc.subjectgene expression
dc.subjectgenetic diversity
dc.subjectquantitative trait loci
dc.subjectgenetic markers
dc.titleThe genome and GeneBank genomics of allotetraploid Nicotiana tabacum provide insights into genome evolution and complex trait regulation
dc.typeJournal Article

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Instituto Internacional de Investigación del Arroz (IRRI)