Histopathological alterations in the synganglion of female Rhipicephalus linnaei ticks treated with essential oils of Egletes viscosa and Lippia schaueriana.

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dc.contributorMELISSA CAROLINA PEREIRA, UNIVERSIDADE ESTADUAL PAULISTA; LUIS ADRIANO ANHOLETO, ACADIA UNIVERSITY; MARINA RODRIGUES DE ABREU, UNIVERSIDADE ESTADUAL PAULISTA; KARINA NEOOB DE CARVALHO CASTRO, CNPGL; KIRLEY MARQUES CANUTO, CNPAT; ANA SHEILA QUEIROZ DE SOUZA; MARIA IZABEL CAMARGO-MATHIAS, UNIVERSIDADE ESTADUAL PAULISTA.
dc.creatorPEREIRA, M. C.
dc.creatorANHOLETO, L. A.
dc.creatorABREU, M. R. de
dc.creatorCASTRO, K. N. de C.
dc.creatorCANUTO, K. M.
dc.creatorSOUZA, A. S. Q. de
dc.creatorCAMARGO-MATHIAS, M. I.
dc.date2026-06-08T12:48:35Z
dc.date2026-06-08T12:48:35Z
dc.date2026-06-08
dc.date2026
dc.date.accessioned2026-07-07T04:01:28Z
dc.descriptionThe inappropriate use of synthetic chemical acaricides for tick management has contributed to the selection of acaricideresistant tick strains, thereby stimulating the search for alternative and effective tick control strategies. Among these, the use of essential oils (EOs) derived from plants such as Egletes viscosa Less. (Asteraceae) and Lippia schaueriana Mart. (Verbenaceae) have shown promise in the control of insects and other arthropods. This study aimed to evaluate the effects of E. viscosa and L. schaueriana EOs on the morphohistology of the tick central nervous system (synganglion)—in Rhipicephalus linnaei semi-engorged females. The morphological alterations in the synganglion were assessed using histopathological and semi-quantitative analyses. The EOs, extracted via hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC–MS), revealed 27 constituents in E. viscosa and 18 in L. schaueriana, with cis-isopinocarveol acetate and piperitenone oxide identified as the predominant compounds, respectively. Histological and semi-quantitative analyses of the synganglion in EO-exposed females revealed dose-dependent alterations that were more severe than the mild vacuolization observed in the ethanol control group, primarily characterized by disruptions in the external membrane structures (neurilemma and perineurium), degeneration of the cortical region with hypertrophic, pyknotic, and fragmented neuronal nuclei, cytoplasmic vacuolization, and neuropil fiber disorganization. These findings suggest that the essential oils of E. viscosa and L. schaueriana induce histopathological damage in the synganglion, including neuronal cell damage and potentially impairing other central nervous system-mediated functions, such as feeding and reproduction. This supports the potential of these oils as candidates for the development of novel plant-based acaricides.
dc.identifierArthropod-Plant Interactions, v. 20, 47, 2026.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1187358
dc.identifierhttps://doi.org/10.1007/s11829-026-10256-3
dc.identifier.urihttp://hdl.handle.net/123456789/450753
dc.languageeng
dc.rightsopenAccess
dc.subjectEctoparasita
dc.subjectEgletes viscosa
dc.subjectLippia schaueriana
dc.subjectSynganglion
dc.subjectCarrapato
dc.subjectAcaricida
dc.subjectMacela
dc.subjectÓleo Essencial
dc.titleHistopathological alterations in the synganglion of female Rhipicephalus linnaei ticks treated with essential oils of Egletes viscosa and Lippia schaueriana.
dc.typeArtigo de periódico

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