Campylobacter Jejuni Increases Transcribed Il-1Β and Causes Morphometric Changes in the Ileal Enterocytes of Chickens
No hay miniatura disponible
Fecha
Título de la revista
ISSN de la revista
Título del volumen
Editor
Fundação APINCO de Ciência e Tecnologia Avícolas
Resumen
Descripción
Campylobacteriosis is a worldwide foodborne zoonosis disease caused by Campylobacter jejuni . This microorganism is considered a commensal bacterium in chicken hosts. C. jejuni produces epithelial cell modifications and induces a cytokine gene transcription innate immunity repertoire. In the present study, we describe the invasiveness, morphological cellular modifications, and transcript level expressions of innate immune cytokines from C. jejuni -inoculated chicken ileum explants. C. jejuni was internalized by epithelial ileum cells at 15 minutes postinoculation (p.i.) and was detected intracellularly for 4hs (p.i.). Inoculated explants displayed significant increases in cell height. C. jejuni induced a significant elevation of Transforming Growth Factor Beta 3 (TGF- β 3) and Interleukin-1 β (IL-1 β ) transcripts. In conclusion, C. jejuni is internalized in explanted epithelial ileum cells, produces morphological cell modifications, and induces gene transcription of both anti-inflammatory and pro-inflammatory cytokines.
Palabras clave
Agrociencias